Archive for the 'Vitamins & Supplements' Category

Apr 10 2009

Omega-3 protect prostates from cancer

Increased intake of omega-3 fatty acids protect against advanced prostate cancer, according to new research from the University of California San Francisco.
According to findings published in the journal Clinical Cancer Research, omega-3 essential fatty acids may reduce prostate cancer risk by modifying a specific variant of the COX-2 gene, a known contributor to chronic inflammation.
The variant known as rs4647310 is linked to a five-fold increased risk of advanced prostate cancer, report the researchers, but high intakes of omega-3 may reduce the risk, even if people carry the COX-2 variant.
The highest average intakes of omega-3 fatty acids were associated with a 63 percent reduction in the risk of aggressive prostate cancer, compared to men with the lowest amount of long chain omega-3 fatty acids, said the researchers.
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The study adds to a growing body of evidence linking omega-3 to potential cancer benefits. Results in the journal Cancer Epidemiology, Biomarkers & Prevention reported that higher intake of the omega-3 fatty acids DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) may cut the risk of developing prostate cancer by 40 per cent. Interestingly, the new study reports no relationship between fish intake and the risk of prostate cancer.
Over half a million new cases of prostate cancer are diagnosed every year worldwide, and the cancer is the direct cause of over 200,000 deaths. More worryingly, the incidence of the disease is increasing with a rise of 1.7 per cent over 15 years.

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Feb 04 2009

Resveratrol and 60 Minutes

Seventeen years ago, 60 Minutes first examined the so-called French paradox, which suggested that the French – despite a high fat diet and high consumption of wine – had a remarkably low incidence of heart disease, compared with Americans. Most researchers agreed that there was something in the wine that offered protection, and a few years later, even the highly cautious federal dietary guidelines say that moderate consumption of red wine can be beneficial.

Now, scientists across the country have identified a substance in red wine called resveratrol that they believe might do more than just protect the heart, but could – in very high concentrations – significantly extend life by preventing a number of age related illnesses. If they’re right, we all may soon be taking a pill that could give us an extra decade or two of healthy old age.

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“If the promise holds true, I think this has the chance to change healthcare,” Dr. Christoph Westphal tells correspondent Morley Safer.

Dr. Westphal says we all may soon be taking a drug that just might beat the clock, a simple pill that could delay the inevitable. “Our goal is to prevent and forestall many of the diseases that strike us as we reach 50, 60, and 70. All with one pill.”

Continue Reading »

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Jan 20 2009

Turmeric Component Protects Against Toxic Compound Consumed in Many Meals

Curcumin, the pigment that gives turmeric its yellow color, may reduce the damaging effects of acrylamide (AA), a potential carcinogen created when starchy foods are baked, roasted, fried or toasted.

Swedish scientists first reported on acrylamide’s widespread presence in the food supply in 2002, when they found unexpectedly high levels of acrylamide in carbohydrate-rich foods. This was of concern since the toxin causes cancer in laboratory rats. Other scientists have found that acrylamide causes DNA to fragment, increases formation of damaging reactive oxygen species (ROS) and triggers the death of liver cells. It is also genotoxic, meaning that it damages a cell’s genetic material affecting the cell’s integrity. Genotoxic substances have the potential to be carcinogens and can cause genetic mutations that lead to the development of tumors.

Due to its antioxidant abilities, researchers studied curcumin’s effects on human liver cells exposed to acrylamide. They found that curcumin significantly reduced the production of reactive oxygen species that occurred in acrylamide-treated cells. Curcumin also inhibited the acrylamide-induced DNA fragments and significantly reduced the acrylamide-triggered cell death, indicating curcumin could ameliorate acrylamide’s known genotoxicity.

The researchers believe that curcumin’s effects are likely due to its antioxidant abilities. They concluded, “Consumption of curcumin may be a plausible way to prevent AA-mediated genotoxicity.”

Reference:

Cao J, Liu Y, Jia L, Jiang LP, Geng CY, Yao XF, Kong Y, Jiang BN, Zhong LF. Curcumin Attenuates Acrylamide-Induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging. J Agric Food Chem. 2008 Nov 14. Published Online Ahead of Print.

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Jan 20 2009

Grape Seed Extract May Stop Bacteria Involved in Bad Breath and Gum Disease

A new study suggests that grape seed extract may inhibit the bacteria known to cause bad breath and gum disease.

Periodontitis is a gum disease that destroys the soft tissue and bone supporting the teeth. Thirty to 50 percent of the US population suffers from the condition, which is thought to be the second most common disease worldwide.

In an in vitro study, researchers investigated whether grape seed extract could inhibit Porphyromonas gingivalis and Fusobacterium nucleatum, bacteria responsible for both periodontitis and bad breath. The researchers tested the effects of grape seed extract (97 percent polyphenols) on these two anaerobic bacteria.

The results indicated that grape seed extract exhibited antibacterial activity against the two strains. Moreover, the grape seed extract could penetrate the biofilm that surrounded the bacteria. Biofilms serve to protect bacteria against antimicrobial agents and dental plaque’s biofilm is particularly complex.

Grape seed extract also had an antioxidant activity higher than vitamins C and E, according to measures taken with the Trolox equivalent antioxidant capacity (TEAC) test. This was important to the findings of the study because gum disease originates due to the bacteria’s presence and its biofilm protection, but the disease progresses because of an excess release of reactive oxygen species that trigger the inflammatory process. Grape seed extract’s antioxidant abilities may quench the free radicals implicated in the progression of gum disease.

The researchers concluded, “These findings indicated that GSE could be used in oral hygiene for the prevention of periodontitis.”

Reference:

Furiga A, Lonvaud-Funel A, Badet C. In vitro study of antioxidant capacity and antibacterial activity on oral anaerobes of a grape seed extract. Food Chemistry. 15 April 2009;113( 4);1037-1040. Available online prior to April publication date.

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Jun 10 2008

Scientists Propose Mechanism Behind Niacin’s Ability to Raise “Good” Cholesterol Breaking News

A new study investigating the mechanism by which niacin is able to raise HDL, the “good” cholesterol, has found that the B vitamin may exert its effects on the liver by inhibiting the excretion of HDL.

Niacin is known to increase plasma HDL levels, but the mechanism by which niacin exerts its action is not clearly understood. Therefore, scientists undertook a new study to clarify exactly how niacin is able to raise HDL.

In the body, a substance called “a beta chain” takes up HDL and therefore reduces the level of good cholesterol. Researchers investigated niacin’s effects on beta-chain’s ability to uptake HDL, by incubating human liver cells with niacin. When they did this a 27 percent reduction in the presence of beta chains on the cell surface was observed. Furthermore, the scientists observed a 35 percent reduction in the uptake of HDL in cells treated with niacin.

The results of the in vitro study suggested that niacin stops the liver from removing HDL from the blood, allowing the body to preserve its high plasma HDL levels.

Griffin Medical Group prescribes pharmaceutical sustained release niacin (generic Niaspan) to raise HDL levels. Starting dose is 500mg each day with food. This product may cause a flushing episode that can last up to 30 minutes. This flushing will subside over time with continued use. You may want to take SR Niacin with ½ an aspirin to control the flushing during the initial phase of treatment.

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Reference:

Zhang LH, Kamanna VS, Zhang MC, Kashyap ML. Niacin inhibits surface expression of ATP synthase {beta} chain in HepG2 cells: implications for raising HDL. J Lipid Res. 2008 Jun;49(6):1195-201.

Yours in health,

Griffin Medical Group

www.griffinmedical.com

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Jun 04 2008

New hints seen that the antioxidant component of red wine (resveratrol) slows aging

Wednesday, June 4, 2008

Red wine is much more potent than was thought in extending human lifespan, researchers say in a new report that is likely to give impetus to the rapidly growing search for longevity drugs.

The study is based on dosing mice with pharmaceutical resveratrol, an ingredient of some red wines. Some scientists are already taking pharmaceutical resveratrol in capsule form.

The report is part of a new wave of interest in drugs that may enhance longevity. On Monday, Sirtris, a startup founded in 2004 to develop drugs with the same effects as resveratrol, completed its sale to GlaxoSmithKline for $720 million. Continue Reading »

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Jun 03 2008

Nettle Root

Published by under Vitamins & Supplements

The roots of the stinging nettle are useful for male hormone balance. Extracts known as lignans derived from the roots have the ability to bind sex hormone binding globulin (SHBG). When SHBG is bound, this may allow for more unbound, or free (bioavailable) testosterone to be available for biological processes and this may prevent SHBG from binding to the prostate gland, which may prevent prostatic enlargement via SHBG binding 5. Bioavailable testosterone represents the fraction of circulating testosterone that readily enters cells and better reflects the bioactivity of testosterone. The better bioactivity means a more healthful benefit from testosterone.1 Stinging nettle root constituents also act to control the growth of prostatic cells and resultant symptoms.2-3 Nettle root also contains another constituent known as beta-sitosterol which has positive effects on testosterone levels and prostate health.4

Griffin Medical Group recommends 250mg twice a day between meals which may allow more free testosterone.

Yours in health,

Griffin Medical Group

www.griffinmedical.com

1. Hyrb D et al. The effect of extracts of the roots of the stinging nettle (Urtica dioca) on the interaction of SHBG with its receptor on human prostatic membranes. Planta Med, 1995, 61:31-32.
2. Konrad L, Muller HH, Lenz C, et al. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med 2000;66:44-7.
3. Lichius JJ, Muth C. The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse. Planta Med 1997;63:307-10.
4. Durak I, Biri H, Devrim E, et al. Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biol Ther 2004;3:855-7.
5. Schottner M, Gansser D, Spiteller G, et al. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Med 1997;63:529-32.

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May 21 2008

Quality Assurance Alert – Toxic Chemicals in Raw Materials

As you know by now, Griffin Medical Group only prescribes pharmaceutical vitamins and supplements. We are one of only a few medical groups that seek quality in all the products we recommend. We feel that we are the leader in quality assurance. Contamination in natural products is a huge issue, whether the material comes from China, India, Europe or the United States. It is not where the material comes from that matters, but how thoroughly it was tested for purity before it gets put into a product and sold. Here are a few of the solvent tainted raw materials that we have been advised of by the pharmaceutical companies we work with. The following raw materials were deemed unacceptable to pharmaceutical supplement companies. Continue Reading »

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Apr 21 2008

Key Nutrients Reverse Brain Aging Now Available in a Prescription formula

For years, the health of your brain cells was largely considered a one-shot deal: Your neurons had a single non-dividing lifespan — and once they were gone, there was no replacing them.

Making matters worse, any further loss of neurites and dendrites (the branches that form your brain’s massive communication network) could take what would be an otherwise normal loss of brain cells and turn it into a much more serious (and equally irreversible) condition — one marked by anything from minor physical and behavioral impairments to a state of complete senility.

Luckily, the scientific community has since done an about face on this particular matter.

More recent research has revealed that brain cells can replace themselves and regrow their communication networks, if given the right environment. In fact, just by boosting your intake of a few key nutrients, you can improve cognitive health — and even turn back the clock where cognitive decline has already started to settle in.

Among these nutrients, acetyl carnitine could be considered the most important. Laboratory studies have shown that this nutrient increases the revitalizing effects of nerve growth factor (NGF) on brain cells — helping to boost neurite outgrowth a full 100 times greater than NGF alone.1 And when taken in combination with acetyl carnitine arginate, the two act synergistically to boost the production of key neurotransmitters, like GABA and glutamate.2

These powerful effects are reflected in a number of human trials—all of which have shown that acetyl carnitine yields significant improvements in cognition.3

Uridine is also an important and little known ingredient for brain function—it provides the necessary components for cell membrane growth and memory-related neural signaling. In vitro analysis has revealed that human brain cells exposed to uridine experience increased neurite outgrowth and regeneration — results that carried over in vivo, when tested in aged rats.4-5

Similar applications can be seen with gotu kola, an Indian plant with a long history of use in Ayurvedic preparations for senility, epilepsy, and other nervous conditions. Studies performed in the last decade have only reinforced this reputation: Scientists have identified two of gotu kola’s unique compounds — asiaticosides and asiatic acid — as being particularly active, sparking repair of damaged neurons and higher brain functioning in both animal and in vitro studies.6

Complimentary Prescriptions, Neuron Growth Factors (NGF™)

A Rx formula that improves brain function by restoring the outgrowth of neurites on our brain cells. Neurites are the branch-like extensions (axons and dendrites) on brain cells where communication takes place. As we age, a reduction in this neurite network can occur, resulting in a corresponding loss of brain function.

Affected processes can include:

  • Alertness, focus and concentration
  • Cognitive (thinking) ability
  • Short term memory
    • Name, face recall
    • “What was I just saying…?”
    • “What did I come in here for…?”
    • “Where did I put my _____?
  • Ability to retain new information – “How do I work the remote again?”
  • Even hearing and spatial memory (sense of “where I am”) can be affected by neurite loss.

NGF is different from other kinds of brain products. Unlike other formulas NGF enhances brain function by actually improving the structure of brain cells through enhanced neurite outgrowth. Every aspect of brain function can benefit. NGF contains nutrients that have been shown to increase neurite outgrowth and help restore and enhance the structural basis of the brain’s neural communications network.

NGF contains acetyl l-carnitine (ALC) which has been shown to increase nerve growth factor activity as much as 100-fold. ALC increases the number of nerve growth factor receptor sites on brain cells, thereby enhancing the rate of neurite outgrowth. A related compound, acetyl carnitine arginate, works synergistically by mimicking the action of nerve growth factor itself.

Another ingredient, uridine, has been shown to regrow axons and dendrites during growth and development stages, as well as in older animals. Uridine has also been shown to improve cognitive function.

Gotu kola contains several active principals called asiaticosides. These improve cognition in older animals while stimulating axon-dendrite growth and out branching in key areas of the brain. Gotu kola has been used for centuries as a brain tonic in Indian and Chinese medicine and its use has been recorded for 2,000 years.

Gingko biloba has been shown to reduce the free radical oxidative stress produced by the presence of senile plaque in older brains. It is also able to improve undesirable structural changes to neurites caused by the presence of senile plaque. Gingko is a well-known promoter of blood circulation in the brain.

Recommended Dosage: See link below:

https://www.griffinmedical.com/shop/product.php?productid=342&cat=0&page=1

Griffin Medical Group (714) 549-6500

www.griffinmedical.com

References:

  1. Tagliatatela G, Angelucci L, Ramacci MT, et al. “Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor.” Brain Res Dev Brain Res. 1991 Apr 24;59(2):221-30.
  2. Westlund KN, LU Y, Werrbach-Perez K, et al. “Effects of nerve growth factor and acetyl-L-carnitine arginyl amide on the human neuronal line HCN-1A. Int J Dev Neurosci. 1992 Oct;10(5):361-73.
  3. Montgomery SA, Thai LJ, Amrein R. “Meta-analysis of double-blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease.” Int Clin Psychopharmacol. 2003 Mar;18(2): 61-71.
  4. Pooler Am, Guez DH, Benedictus R, et al. “Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected].” Neuroscience. 2005; 134(1):207-14.
  5. Wang L, Pooler AM, Albrecht MA, et al. “Dietary uridine-5-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. 2005;27(1):137-45.
  6. Soumyanth A, Zhong YP, Gold SA, et al. “Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple fractions increasing neurite elongation in-vitro.” J Pharm Pharmacol. 2005 Sept;57(9):1221-9.

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Apr 11 2008

Key Nutrients Reverse Brain Aging Now Available in a Prescription formula

Published by under Vitamins & Supplements

For years, the health of your brain cells was largely considered a one-shot deal: Your neurons had a single non-dividing lifespan — and once they were gone, there was no replacing them. Continue Reading »

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Mar 03 2008

Creatine Monohydrate

What exactly is Creatine?

Creatine (Cr) is a naturally occurring amino acid found in muscle tissue of humans and animals. It plays an important role in fueling muscles. The human body has 100 to 115 grams of creatine stored in the form of creatine phosphate or phosphocreatine. Approximately 95% of the body’s creatine supply are found in the skeletal muscles. The remaining 5% are scattered throughout the rest of the body, with the highest concentrations in the heart, brain and testes. Creatine is easily absorbed from the intestinal tract into the bloodstream. When dietary consumption is inadequate to meet the body’s needs, a limited supply can be synthesized from the amino acids arginine, glycine and methionine. This creatine production occurs in the liver, pancreas and kidneys. Continue Reading »

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Dec 18 2007

Creatine, Astragalus and Ginseng May Enhance Strength Training in Seniors

Older strength trainers who supplement with a combination of creatine, ginseng and astragalus experience increased strength, vigor and lean mass, researchers recently reported. The scientists investigated the effects of these supplements on 44 adults aged 55 to 84 years who were participating in a 12-week strength-training program. Continue Reading »

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Dec 18 2007

Creatine Review Investigates Amino Acid’s Supportive Role in Muscular Dystrophy Patients

A new review of the medical literature indicates that the amino acid creatine may increase muscle strength in muscular dystrophy patients. There are 30 or more genetic and hereditary muscle diseases that fall under the category of muscular dystrophies. Continue Reading »

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Dec 18 2007

Creatine and Whey Protein: Consuming Before Load-Bearing Exercise Produces Best Results

Consuming creatine monohydrate and whey protein immediately prior to load-bearing exercise results in greater gains in muscle and strength compared to taking the supplements at other times during the day, a soon-to-be-published study reports. Continue Reading »

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Dec 18 2007

Selenium and Vitamins B6 and B12 Levels Linked to Active Life in Seniors

A new study indicates that women who have high serum concentrations of selenium and vitamins B6 and B12 have a significantly reduced risk of age-related disability in conducting daily activities, leading researchers to suggest that nutritional status is an important factor in helping the elderly live an active life longer. Continue Reading »

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Dec 18 2007

Folic Acid and Vitamin B12 Linked to Healthy Bones in Japanese Study

Folic acid and vitamin B12 supplements reduce the risk of hip fractures in elderly Japanese patients following a stroke, researchers report in a new study in the Journal of the American Medical Association(JAMA). Stroke increases the risk of subsequent hip fracture by 2 to 4 times. Continue Reading »

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Nov 08 2007

Pharmaceutical Grade Vitamins (supplements) vs. Regular Vitamins (supplements)

Published by under Vitamins & Supplements

Vitamins are necessary for human life and health. They are required in minute amounts, and with the exception of Vitamin B12, cannot be manufactured in your bodies. These organic compounds need to be obtained from diet, and if deprived of a particular vitamin, you will suffer from disease specific to that vitamin. It is a matter of record that you are not getting enough vitamins. Though we Americans are living longer, our quality of life leaves much to be desired.

The thirteen different vitamins are classified into two main categories:

· Water Soluble Vitamins – They dissolve easily in water. They are Vitamin C and the eight types of Vitamins B, B-1, B-2, B-3, B-5, B-6, B-7, B-9, and B-12.
· Fat Soluble Vitamins – With the help of lipids, they are absorbed through the intestinal tract. These vitamins are Vitamins A. D, E, and K.

The term Vitamin does not mean to include essential nutrients, such as, dietary minerals, essential fatty acids, or essential amino acids; neither does it mean to include other nutrients that just promote health, and may not be essential.

The Different Grades of Vitamins
Vitamin supplements are taken by more than 75% of the world’s population. With the plethora of different brands, it becomes difficult to know what is what. Vitamins and other nutritional supplements are made from three different grades of raw materials:

· Pharmaceutical Grade – It meets pharmaceutical standards
· Food Grade – It meets standards for human consumption
· Feed Grade – It meets standards for animal consumption

The main difference is of quality and purity. Due to the addition of various other substances, no product is 100% pure. Pharmaceutical Grade Vitamins must be in excess of 99% purity containing no binders, fillers, excipients – substances used as diluents for a drug – dyes, or unknown substances. Regular Vitamins of the other two grades are available as Over The Counter (OTC) products, whereas pharmaceutical grade vitamins are only available through prescriptions.

Pharmaceutical grade vitamins are formulated to yield a higher degree of bioavailability – the degree at which the vitamin is absorbed into a living system. As these vitamins can be absorbed into your body quickly, they improve and enhance the quality of your life rapidly.

Of late, the American vitamin and supplement industry has gained a bad reputation, and many feel it is rightly deserved. People walk into stores and pharmacies to buy regular vitamins. In some of the cases, the ingredients specified on the label are not in conformity with what they find inside the bottle. A variety of ingredients do not absorb into the body. The ingredients could be rancid or stale. One of the biggest culprits is omega 3 fish oil. It is probably the most bastardized supplement in the market today. Most over the counter fish oil is rancid and may contain dioxins, PCBs, aflatoxins, herbicides, pesticides, fungicides as well as unacceptable levels of heavy metals (lead, mercury, cadmium, arsenic and aluminum). Fish oil must be ultra-purified and Pharmaceutical grade. At Griffin Medical Group we prescribe our patients an ultra-purified pharmaceutical fish oil that I have taken for the past two years.  

More and more people are opting for pharmaceutical grade vitamins and supplements, as they are available through prescriptions from doctors and licensed medical practitioners. Pharmaceutical grade vitamins, vis-à-vis regular vitamins, have been tested for their quality and ability to give results. They are tested by third parties to confirm that the bottles contain what they profess to contain.

 

Yours in health, 

 

       Dr. Alan C. Ivar

 

www.griffinmedical.com

 

A special thank you goes out to Cathy Taylor for contributing to this article.     

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Supply of hospital pharmacies operating externally due to cost savings will continue to grow all over the next years. Even today, 90% of all pharmacies pribolnichnyh organized in cooperation provisioning This shows that the Canadian pharmacy online has become not take seriously the business partner compared with the pharmaceutical industry. However, the development of recent years shows that the industry sees its price registration stronger with the number of sales, thus strengthening the competitiveness of supplying hospital pharmacies in the long term due to more efficient logistics and a lot of sales.