Information on Anti Aging, Age Management, Bio Identical Hormone Replacement Therapy.

May 08 2008

Turmeric Component Maintains Healthy Blood Sugar Levels in Animal Study

Published by under Turmeric

Curcumin, the compound in turmeric responsible for its yellowish color, improved insulin resistance and glucose tolerance in diabetic mice, according to the results of a new study.

The study authors investigated the effect of curcumin on insulin resistance and glucose tolerance in male diabetic mice and age-matched lean non-diabetic controls. Insulin resistance occurs when the body, after exposure to a constant onslaught of high blood sugar, needs to produce more and more insulin in order to feel insulin’s blood sugar stabilizing effects.

Both non-diabetic and diabetic mice were fed with or without curcumin for six weeks. At the study’s conclusion, there were a number of beneficial effects in the animals given the turmeric component. Curcumin significantly lowered blood glucose and levels of glycosylated haemoglobin HbA(1c), which researchers use as an indicator of blood glucose regulation. Curcumin also suppressed body weight loss in diabetic mice and reduced insulin resistance.

Furthermore, the researchers noted beneficial effects on the liver in the diabetic animals given curcumin. Activity of an enzyme that is important to the conversion of glucose into glycogen, which serves as the body”s main carbohydrate store, was higher in the diabetic mice given curcumin compared to the diabetic mice that did not receive the compound. The higher activity of the enzyme seen in the diabetic animals given curcumin is thought to inhibit the post-meal rise in glucose.

The turmeric-derived component also significantly lowered cholesterol and triglyceride concentrations and significantly reduced lipid peroxidation by virtue of its ability to raise antioxidant levels in the liver. In mice without diabetes, curcumin had no effect on blood glucose, plasma insulin, and glucose regulating enzyme activities.

The study authors wrote, “These results suggest that curcumin seemed to be a potential glucose-lowering agent and antioxidant in type 2 diabetic mice, but had no effect in non-diabetic mice.”


Seo KI, Choi MS, Jung UJ, Kim HJ, Yeo J, Jeon SM, Lee MK. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res. 2008 Apr 8. Published online ahead of print.

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Apr 21 2008

Key Nutrients Reverse Brain Aging Now Available in a Prescription formula

For years, the health of your brain cells was largely considered a one-shot deal: Your neurons had a single non-dividing lifespan — and once they were gone, there was no replacing them.

Making matters worse, any further loss of neurites and dendrites (the branches that form your brain’s massive communication network) could take what would be an otherwise normal loss of brain cells and turn it into a much more serious (and equally irreversible) condition — one marked by anything from minor physical and behavioral impairments to a state of complete senility.

Luckily, the scientific community has since done an about face on this particular matter.

More recent research has revealed that brain cells can replace themselves and regrow their communication networks, if given the right environment. In fact, just by boosting your intake of a few key nutrients, you can improve cognitive health — and even turn back the clock where cognitive decline has already started to settle in.

Among these nutrients, acetyl carnitine could be considered the most important. Laboratory studies have shown that this nutrient increases the revitalizing effects of nerve growth factor (NGF) on brain cells — helping to boost neurite outgrowth a full 100 times greater than NGF alone.1 And when taken in combination with acetyl carnitine arginate, the two act synergistically to boost the production of key neurotransmitters, like GABA and glutamate.2

These powerful effects are reflected in a number of human trials—all of which have shown that acetyl carnitine yields significant improvements in cognition.3

Uridine is also an important and little known ingredient for brain function—it provides the necessary components for cell membrane growth and memory-related neural signaling. In vitro analysis has revealed that human brain cells exposed to uridine experience increased neurite outgrowth and regeneration — results that carried over in vivo, when tested in aged rats.4-5

Similar applications can be seen with gotu kola, an Indian plant with a long history of use in Ayurvedic preparations for senility, epilepsy, and other nervous conditions. Studies performed in the last decade have only reinforced this reputation: Scientists have identified two of gotu kola’s unique compounds — asiaticosides and asiatic acid — as being particularly active, sparking repair of damaged neurons and higher brain functioning in both animal and in vitro studies.6

Complimentary Prescriptions, Neuron Growth Factors (NGF™)

A Rx formula that improves brain function by restoring the outgrowth of neurites on our brain cells. Neurites are the branch-like extensions (axons and dendrites) on brain cells where communication takes place. As we age, a reduction in this neurite network can occur, resulting in a corresponding loss of brain function.

Affected processes can include:

  • Alertness, focus and concentration
  • Cognitive (thinking) ability
  • Short term memory
    • Name, face recall
    • “What was I just saying…?”
    • “What did I come in here for…?”
    • “Where did I put my _____?
  • Ability to retain new information – “How do I work the remote again?”
  • Even hearing and spatial memory (sense of “where I am”) can be affected by neurite loss.

NGF is different from other kinds of brain products. Unlike other formulas NGF enhances brain function by actually improving the structure of brain cells through enhanced neurite outgrowth. Every aspect of brain function can benefit. NGF contains nutrients that have been shown to increase neurite outgrowth and help restore and enhance the structural basis of the brain’s neural communications network.

NGF contains acetyl l-carnitine (ALC) which has been shown to increase nerve growth factor activity as much as 100-fold. ALC increases the number of nerve growth factor receptor sites on brain cells, thereby enhancing the rate of neurite outgrowth. A related compound, acetyl carnitine arginate, works synergistically by mimicking the action of nerve growth factor itself.

Another ingredient, uridine, has been shown to regrow axons and dendrites during growth and development stages, as well as in older animals. Uridine has also been shown to improve cognitive function.

Gotu kola contains several active principals called asiaticosides. These improve cognition in older animals while stimulating axon-dendrite growth and out branching in key areas of the brain. Gotu kola has been used for centuries as a brain tonic in Indian and Chinese medicine and its use has been recorded for 2,000 years.

Gingko biloba has been shown to reduce the free radical oxidative stress produced by the presence of senile plaque in older brains. It is also able to improve undesirable structural changes to neurites caused by the presence of senile plaque. Gingko is a well-known promoter of blood circulation in the brain.

Recommended Dosage: See link below:

Griffin Medical Group (714) 549-6500


  1. Tagliatatela G, Angelucci L, Ramacci MT, et al. “Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor.” Brain Res Dev Brain Res. 1991 Apr 24;59(2):221-30.
  2. Westlund KN, LU Y, Werrbach-Perez K, et al. “Effects of nerve growth factor and acetyl-L-carnitine arginyl amide on the human neuronal line HCN-1A. Int J Dev Neurosci. 1992 Oct;10(5):361-73.
  3. Montgomery SA, Thai LJ, Amrein R. “Meta-analysis of double-blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease.” Int Clin Psychopharmacol. 2003 Mar;18(2): 61-71.
  4. Pooler Am, Guez DH, Benedictus R, et al. “Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected].” Neuroscience. 2005; 134(1):207-14.
  5. Wang L, Pooler AM, Albrecht MA, et al. “Dietary uridine-5-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. 2005;27(1):137-45.
  6. Soumyanth A, Zhong YP, Gold SA, et al. “Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple fractions increasing neurite elongation in-vitro.” J Pharm Pharmacol. 2005 Sept;57(9):1221-9.

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Apr 11 2008

Key Nutrients Reverse Brain Aging Now Available in a Prescription formula

Published by under Vitamins & Supplements

For years, the health of your brain cells was largely considered a one-shot deal: Your neurons had a single non-dividing lifespan — and once they were gone, there was no replacing them. Continue Reading »

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Mar 18 2008

Study: After hormone therapy, new cancers arise

Published by under Anti Aging - Hormones

The first follow-up of a landmark study of hormone use after menopause shows heart problems linked with the pills seem to fade after women stop taking them, while surprising new cancer risks appear.

That heart trouble associated with hormones may not be permanent is good news for millions of women who quit taking them after the government study was halted six years ago because of heart risks and breast cancer.

But the new risks for other cancers, particularly lung tumors, in women who had taken estrogen-progestin pills for about five years puzzled the researchers and outside experts.

Those risks “were completely unanticipated,” said Dr. Gerardo Heiss of the University of North Carolina in Chapel Hill, lead author of the follow-up analysis. Continue Reading »

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Mar 18 2008


By Dr. James Howenstine, MD.
November 5, 2005

Lack of iodine is widespread in the United States today. For many years iodine was added to bread in generous quantities which prevented iodine deficiency. Each slice of bread contained 150 mcg. of iodine filling the whole days RDA of iodine In 1960 the average diet consumed about 1 mg. of iodine daily with bakery products accounting for about 75 % of the total. This quantity of iodine was enough to decrease the thyroid glands ability to absorb radioactive iodine and it was also sufficient to prevent excess release of thyroid hormone thus preventing many cases of hyperthyroidism (Grave’s Disease). Continue Reading »

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Mar 18 2008

Sorting Through the Choices For Menopause Hormones

March 11, 2008; 

Excerpt from the Wall Street Journal

Amid all the confusion over hormone-replacement therapy(HRT) for women, one key aspect is often overlooked: Not all HRT products are the same.

The big Women’s Health Initiative that has been generating headlines since 2002 studied women using Premarin and Prempro, both made by Wyeth, which were the state-of-the-art hormone drugs many years ago. Today, estrogen and progesterone are available in forms that are much closer to what women lose in menopause. While the Food and Drug Administration has said it thinks all HRT products pose the same risks, a growing number of doctors and patients prefer the newer varieties. Continue Reading »

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Mar 18 2008

Grumpy Old Men: Maybe It’s A Question of Testosterone

February 26, 2008;

They’re bullish on testosterone here at the 6th Annual World Congress on the Aging Male.

Physicians and researchers from around the world gathered to review the latest findings on what low levels of the male hormone means for men, how replacing it might help and why it hasn’t caught on broadly.

“If we had a drug that could restore sexual function in men, make them stronger, build their bones, reduce fat and get rid of the blues, you’d say, ‘Oh my God, why doesn’t everybody know about it?’ ” says Abraham Morgentaler, a urologist at Harvard Medical School and director of the Men’s Health Boston clinic. “There is a drug like that — but the public associates testosterone with cheating and illicit behavior and the fact that 40 years ago, it was thought to give people prostate cancer.” Continue Reading »

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Mar 03 2008

Creatine Monohydrate

What exactly is Creatine?

Creatine (Cr) is a naturally occurring amino acid found in muscle tissue of humans and animals. It plays an important role in fueling muscles. The human body has 100 to 115 grams of creatine stored in the form of creatine phosphate or phosphocreatine. Approximately 95% of the body’s creatine supply are found in the skeletal muscles. The remaining 5% are scattered throughout the rest of the body, with the highest concentrations in the heart, brain and testes. Creatine is easily absorbed from the intestinal tract into the bloodstream. When dietary consumption is inadequate to meet the body’s needs, a limited supply can be synthesized from the amino acids arginine, glycine and methionine. This creatine production occurs in the liver, pancreas and kidneys. Continue Reading »

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Feb 25 2008

BBL (Broadband Light) – PhotoFacial – Skin Rejuvination

Published by under Aesthetics,Photo Facial

(Also referred to as IPL, Photorejuvenation, or “Photofacial”)
The Sciton BBL Treatment is one of the most advanced Intense Pulse Light (IPL) systems available on the market. Our “Photofacial” is a very safe treatment that can lift irregular spots of pigment or discoloration over 10 – 14 days.

What conditions can be treated?

  • Brown spots
  • Age spots
  • Red spots
  • Freckles
  • Hyperpigmentation
  • Redness, flushing,
  • Rosacea and facial spider veins

The treated areas darken immediately following the treatment and then gradually fade over two weeks, yielding younger and fresher looking skin.

There is no downtime associated with a BBL treatment. You can resume normal activities immediately. The BBL can be used safely and effectively on the face, neck, chest and rest of the body.

PhotoFacial - Skin RejuvinationPhotoFacial Skin Rejuvination

Before ……………………..Post 1 BBL Treatment

Skin RejuvinationSkin Rejuvination

Before ………………………Post 2 BBL treatments

If you would like to be contacted to have questions answered or to schedule and appointment please click here.

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Feb 25 2008


Our effective “weekend” skin peel, the MicroLaserPeel, can literally take years off of your face. This peel treats skin conditions associated with aging and an active lifestyle. You can see real improvements in just a few days. The MicroLaserPeel is an intra-epidermal laser peel that precisely ablates the outermost layers of the skin. The procedure is individually tailored from mild to aggressive depending on the nature of the condition to be corrected.

What conditions can be treated?

  • Wrinkles
  • Scars
  • Acne scars
  • Keratoses
  • Pigmentary problems (sunspots, age spots, “liver spots” etc.)

Following treatment, you will experience smoother, healthier, more vibrant skin, with a significant immediate change in skin texture and tightness. Healing takes 3-4 days. The procedure can be performed on a Thursday or Friday, so you can return to work the following Monday. Symptoms immediately following the procedure resemble a sunburn, with the peeling taking place on the third and fourth days. Most of the redness will begin to fade by the third day, and be easily covered by makeup on the fourth day.

MicroLaserPeel beforeMicroLaserPeel After

Before……….. 5 months post

MicroLaserPeel BeforeMicroLaserPeel after

Before……… Post 2 LaserPeels

If you would like to be contacted to have questions answered or to schedule and appointment please click here.

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Feb 13 2008


Published by under Aesthetics,ProFractional

Dramatically improve wrinkles, scars & sun-damaged skin with ProFractional

If you would like someone to contact you about this procedure please click here.

What is ProFractional?
ProFractional is a quick and comfortable laser procedure with little to no downtime, used for
improving the overall appearance of your skin.
ProFractional uses a laser microbeam to treat thousands of pinpoint areas of your skin. And because
only a fraction of the skin is directly treated with the laser, healing time is quick and downtime is short.

What conditions can be treated with ProFractional?
ProFractional can be used to improve a wide variety of
skin conditions, but is used most for:
 Wrinkles and fine lines
 Post-traumatic scars
 Acne scars
 Age spots
 Sun spots
 Aging and sun-damaged skin

How does the ProFractional laser work?
ProFractional uses laser energy to create thousands of microscopic channels in the skin which are
surrounded by areas of healthy, untreated skin. The zones of untreated skin invigorate the body’s natural
healing process, and the treated areas stimulate production of new collagen, plumping up the skin and
smoothing out wrinkles, lines, scars and other irregularities.

ProFractional Before PictureProFractional After Picture
Before……………. 4 weeks after 3 Treatments

ProFractional - FraxialProFractional

Before………………………4 weeks post 1 ProFractional Tx

Who should consider a ProFractional treatment?
If you are looking for younger looking skin, or to improve scars, wrinkles, or sun damage in a
comfortable treatment with a fast recovery, then you may be an ideal candidate for ProFractional. Ask your
physician if ProFractional is right for you.

Patient Testimonials
“My face feels revived, and my friends have noticed a fresher look! The freckles
and brown spots are gone, and my skin looks and feels younger”.
– Kristina C., Cupertino, CA

“First time in my life I am comfortable putting my hair back”.
– Annette C., Boca Raton, FL

“The ProFractional treatment has greatly reduced my acne scars that have been
bothering me for years. I feel a lot more confident about my appearance now”.
– Paul K, Dallas, TX

“The treatment was very comfortable and I was able to resume my normal activities
the next day”.
– Bill R. Jr., Chicago, IL

“My skin feels smoother, softer, and has a healthier luster. I am very pleased with
the result.”
– Sue T., McFarland, WI

What areas can be treated?
Most skin areas can be treated. Popular areas are the face, neck, chest and hands. You should discuss your
needs with your physician.

What is a ProFractional procedure like?
ProFractional is a fast, comfortable procedure done in your physician’s office. The procedure normally takes
15 – 30 minutes depending on the condition and the size of the area treated. A numbing cream may be
applied in advance to aid in comfort during the procedure.

How many ProFractional treatments will I need?
ProFractional is typically done in a series of 1 – 4 treatments, spaced 3 – 6 weeks apart, depending on
your needs. Your physician will personalize a treatment plan based on the level of improvement you
desire. Your physician may also combine ProFractional with a MicroLaserPeel or other popular aesthetic
procedures to further enhance your treatment results.

What should I expect after treatment?
Immediately following the procedure you may experience a mild redness, resembling a light sunburn
sensation. Complete healing takes only about 1 – 3 days and most patients can get back to work and apply
makeup within 1 – 2 days after the treatment.

What special after-treatment care will I need?
It is important to follow your physician’s instructions which may include some skin care products and
instructions on how to use them. Your skin will be more sensitive to ultra-violet light after the procedure,
so you must avoid direct sun exposure until fully healed. You should always use some level of sun
protection to avoid sun damage and premature aging of your skin.

If you would like someone to contact you about this procedure please click here.

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Jan 24 2008

Vitamin D3 Deficiency Linked to Increased Risk of Heart Disease and Stroke

Published by under Vitamin D3

Low levels of vitamin D3 may increase the risk of heart disease and stroke by as much as 62 percent, scientists reported in a new study. 

A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system. Vitamin D3 receptors have a broad tissue distribution in areas related to cardiovascular health, including vascular smooth muscle, endothelium, and cardiomyocytes (cells in the heart). Continue Reading »

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Jan 10 2008

What is Sermorelin?

Sermorelin is a biological active analog of growth hormone releasing hormone (GHRH) that is produced by the human brain to stimulate production and release of growth hormone by the pituitary gland.Sermorelin stimulates production of the body’s own HGH. It is a truncated analog of growth hormone releasing factor (GRF 1-44) that is naturally produced by the brain to stimulate pituitary production and secretion of HGH.

During youth, ample amounts of GHRH are produced so that the pituitary is able to provide the body with sufficient growth hormone to sustain health, vitality and otherwise normal aspects of form and function. GHRH declines with age causing reduced production and secretion of pituitary HGH and thereby increasing the sequelae of growth hormone insufficiency.

Unlike HGH, Sermorelin affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity, has a better safety profile, and its use for adult hormone deficiency is not restricted.

Sermorelin benefits:

  • Increases natural production of Growth Hormone
  • Improves Physical Performance
  • Improves Immune Function
  • Increases IGF-1
  • Improves sleep quality

While Sermorelin produces the same effects on body composition and provides the other benefits of HGH, it also has some additional and important benefits.

The effects of Sermorelin are regulated at the level of the pituitary gland by negative feedback and by release of somatostatin so that safety concerns associated the HGH overdosing are minimized or completely avoided.

Tissue exposure to HGH released by the pituitary under the influence of Sermorelin is episodic not “square wave”, and therefore, prevents tachyphylaxis by mimicking normal physiology. By stimulating the pituitary it preserves more of the growth hormone neuroendocrine axis that is the first to fail during aging.

Until recently the effects of Growth Hormone Deficiency in adults were unknown. It is now recognized as a specific clinical syndrome with numerous physiological consequences with effects on;

  • Changes in body composition, including central obesity.
  • Lipids in the blood.
  • Muscle strength.
  • Bone composition.
  • Exercise capacity and energy.
  • Cardiovascular risk.
  • Psychological well-being.

Adult Growth Hormone Deficiency (AGHD) can be effectively treated with recombinant human Growth Hormone. A medically supervised HGH program has many benefits that can improve the user’s life on every level imaginable and AAG Health specializes in treating adults who are experiencing symptoms and problems associated with AGHD. Griffin Medical Group prescribes Sermorelin injections for patients with AGHD. Typically, patients inject themselves with a specific dose once a night.

Effects of Sermorelin and HGH Therapy

  • SKIN - Increased skin elasticity, texture, and tightness.
  • ENERGY – Increased energy and emotional stability.
  • BONE – Improved bone strength.
  • SEXUAL POWER – Increased sexual potency and frequency.
  • MUSCLE – Increased muscle strength and mass.
  • FAT – Decreased fat tissue.
  • MEMORY – Improved mental functioning and strength.
  • HEART – Improved cardiovascular strength and lower blood pressure.
  • KIDNEY – Improved kidney function.
  • IMMUNE SYSTEM – Improved immunity and healing.
  • HAIR – Improved hair texture.
  • CHOLESTEROL – Elevated HDL and lowered LDL.

Hormones can be thought of as “messengers” that are produced by the endocrine glands and then sent all over the body to stimulate specified activities. For example, growth, digestion, reproduction, and sexual functions are all triggered by hormones and they all depend on hormones to work properly.

HGH is one of several endocrine hormones such as estrogen, progesterone, testosterone, melatonin and DHEA that decline in production as we age. As its name suggests, human Growth Hormone is an endocrine hormone that makes humans grow.

HGH is a complex protein molecule of 191 amino acids linked in a specific sequence. It is secreted in pulses by the pituitary gland. These pulses vary between 10 and 30 per day and can be strengthened by exercise. For years, doctors have prescribed HGH for children who needed a growth boost but growth deficiencies do not just affect children, they can be a significant problem for adults too. HGH is critical for tissue repair, healing, muscle growth, bone strength, brain function, physical and mental health, energy, and metabolism.

Somatropin, or Somatotropin, is the man-made version of human Growth Hormone. Griffin Medical Group prescribes Omnitrope. It is available only by prescription and administered by injection.

HGH is produced at a rate that peaks during adolescence, at time when normal growth is accelerated. The production of HGH decreases with age, 14% each year on average. Humans normally produce about 500 micrograms of HGH daily at age 20.By age 80, the daily production falls to 60 (or less) micrograms. Many doctors consider IGF-1 levels below 200 to be HGH deficient and a diagnosis on Adult Onset Growth Hormone Deficiency Syndrome is made.

In the month of August of 1996, the FDA approved recombinant human Growth Hormone for the use in adult patients for the first time. Before, it was approved it only was authorized for use to promote growth in short children with growth deficiencies. Now HGH can be prescribed for deficient adults to treat Adult Onset Growth Hormone Deficiency Syndrome.

Griffin Medical Group offers, to qualified individuals based on medical necessity, HGH therapy in the form of medically supervised programs that are designed to safely replenish and replace your body’s own production of HGH.

For most people the pituitary gland produces sufficient HGH to retain a youthful appearance until age 35 or so. Then, somewhere between age 40 and 50, the body’s ability to produce HGH declines to the point where the signs of Adult Growth hormone Deficiency (AGHD) begin to show.

Signs of Adult Onset Growth Hormone Deficiency (AGHD):

  • SKIN Skin loses elasticity and becomes thinner which causes wrinkles.
  • ENERGY Loss of vigor and stamina.
  • BONE Bones lose strength. Tendency toward osteoporosis.
  • SEXUAL POWER Loss of sexual powers and libido.
  • MUSCLE Muscles lose strength and mass.
  • FAT Fat tissue increases and accumulates.
  • MEMORY Memory begins to fade.
  • HEART Heart muscle loses strength.
  • KIDNEY Decreased kidney function.
  • IMMUNE SYSTEM Decreased immunity and increased healing time.
  • HAIR Hair becomes thinner and loses color.
  • CHOLESTEROL Increased cholesterol level.

The first major study showing the promise of HGH therapy was published in the New England Journal of Medicine (Rudman; 323:1-6 1990). This study was orchestrated by the renowned Dr. Daniel Rudman. It divided 21 men (between the ages of 60 and 80) with IGF-1 levels less than 350 IU per liter into two groups: 12 test subjects and 9 control subjects.

A 6-month period of data collection was followed by a 6-month period in which the 12 test subjects received HGH injections and the 9 control subjects did not. The results were promising: increases in lean muscle mass, decreases in adipose fat tissue, and increases in vertebral bone height. All test subjects had measurable increases in HGH levels, as measured by IGF-1 blood values.

The control group had none of these results. The effects of six months of human growth hormone on body mass and adipose-tissue mass were equivalent in magnitude to the changes incurred during the 10 to 20 years of aging.

Since Rudman’s landmark study, leading doctors and healthcare professionals worldwide have performed many studies that all come to the same conclusion – HGH therapy works. For a complete background on recent and past HGH studies and information on HGH therapy in general, the book entitled “Grow Young With HGH” by Dr. Ronald Klatz (ISBN 0-06-098434-1) is fascinating reading and a “must read”.

The nervous system and brain are made up of cells called neurons, which are permanent and never grow back once damaged. HGH stimulates the repair and rejuvenation of these particular neurons. The proteins in the brain that are responsible for storing our memories are also affected in a positive way.

Learning, memory, and intelligence all depend on adequate supplies of HGH. According to a team of Swedish Scientists they discovered why HGH therapy makes so many people feel so good. HGH acts in the brain exactly like an antidepressant, raising the level of neurotransmitter B- endorphin, which has been called the brain’s own opiate. It also lowers the level of dopamine, which is associated with feelings of agitation. It reverses the outlooks, expectations and attitudes associated with the aging process.

Many other experts expressed that it appears to reduce stress itself, & improves focus and concentration, and builds self esteem and self confidence. HGH can also reverse the decline in memory and cognitive performance.

About 68%of Americans are classified as overweight individuals. Obesity is the 2nd most common preventable death in the United States. Human Growth Hormone may be one of the most effective fat loss regimens ever discovered.

The psychological and emotional symptoms associated with Adult Growth hormone Deficiency (AGHD) include a reduced sense of well being, low energy, vitality, capacity for work, emotional liability, including mood swings, anxiety, depression, and increased social isolation. Important physical signs are increased body fat, especially around the waist (apple shape rather than pear shape), decrease in muscle mass, and thin, wrinkled, or prematurely aged skin. Other symptoms may consist of the following: Reduced cardiac performance, poor sleep, decreased muscle mass and strength, little to no sex drive.

Aging takes place at a more rapid pace when your hormones start to decrease. Once the hormone levels start to decrease, your body starts to change. You tend to gain weight easier, your not as athletic, you tend to be more up tight about things, depressed more frequently, these are all signs that your hormone levels are beginning to drop. Natural hormones are protective and aging is related to the loss of these hormones. Replacing the hormone level to youthful levels delays the aging process.

All of the things that you already know about healthy living are still true, whether you are starting HGH therapy or not. If you are serious about treating your hormone deficiencies with hormone therapy remember that all good programs consist of discipline and commitment in five major areas:

  5. SLEEP

Griffin Medical Group
(714) 549-6550

Dr. Alan Ivar

Dr. Judi Goldstone

Dr. Alvin Yee

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Dec 18 2007

Creatine, Astragalus and Ginseng May Enhance Strength Training in Seniors

Older strength trainers who supplement with a combination of creatine, ginseng and astragalus experience increased strength, vigor and lean mass, researchers recently reported. The scientists investigated the effects of these supplements on 44 adults aged 55 to 84 years who were participating in a 12-week strength-training program. Continue Reading »

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Dec 18 2007

Creatine Review Investigates Amino Acid’s Supportive Role in Muscular Dystrophy Patients

A new review of the medical literature indicates that the amino acid creatine may increase muscle strength in muscular dystrophy patients. There are 30 or more genetic and hereditary muscle diseases that fall under the category of muscular dystrophies. Continue Reading »

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Dec 18 2007

Creatine and Whey Protein: Consuming Before Load-Bearing Exercise Produces Best Results

Consuming creatine monohydrate and whey protein immediately prior to load-bearing exercise results in greater gains in muscle and strength compared to taking the supplements at other times during the day, a soon-to-be-published study reports. Continue Reading »

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Dec 18 2007

Selenium and Vitamins B6 and B12 Levels Linked to Active Life in Seniors

A new study indicates that women who have high serum concentrations of selenium and vitamins B6 and B12 have a significantly reduced risk of age-related disability in conducting daily activities, leading researchers to suggest that nutritional status is an important factor in helping the elderly live an active life longer. Continue Reading »

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Dec 18 2007

Folic Acid and Vitamin B12 Linked to Healthy Bones in Japanese Study

Folic acid and vitamin B12 supplements reduce the risk of hip fractures in elderly Japanese patients following a stroke, researchers report in a new study in the Journal of the American Medical Association(JAMA). Stroke increases the risk of subsequent hip fracture by 2 to 4 times. Continue Reading »

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Dec 04 2007


Published by under Cardiovascular


Its Destructive Role in Cardiovascular, Cognitive and Bone Health

Homocysteine is one of the most destructive compounds found in the human body. Although oxidized LDL cholesterol (the “bad” cholesterol) is commonly considered the arteries’ worst enemy, homocysteine has emerged as an equally powerful threat to heart health. In fact, research now shows that damage from homocysteine paves the way for LDL to have an even more destructive effect on the vascular system, indicating these two agents can work together to cause heart disease. Furthermore, as time goes on, more and more research is uncovering homocysteine’s role in other health conditions such as infertility, depression, cognitive decline and bone fractures.

Homocysteine is considered a primary risk factor for cardiovascular disease including stroke and deep vein thrombosis.1 Elevated blood levels of homocysteine also are considered an independent risk factor for atherosclerosis and thromboembolism (the obstruction of a blood vessel by a clot), and are correlated with a significant risk for coronary, cerebral and peripheral vascular disease, myocardial infarction (heart attacks), peripheral vascular occlusive disease, cerebral vascular occlusive disease, and retinal vascular disease.2 In fact, high homocysteine, even in the absence of other risks, such as smoking and obesity, is a serious but controllable risk factor for heart disease.

Homocysteine is an amino acid commonly found in the blood as a result of protein metabolism. It is mainly derived from another amino acid known as methionine, which is found in a number of food sources primary among them being meat. Blood levels of homocysteine can also be affected by genetic and physiologic factors.

Homocysteine is thought to cause vascular disease because of its effect on blood vessel walls. Homocysteine binds to certain proteins in the body affecting their structure and function. The binding of homocysteine to proteins will degrade and inhibit repair and maintenance of three main vascular connective tissue structures—cartilage, elastin and proteolgycans—making them more susceptible to disease processes, including vascular disease. Homocysteine can damage the cells lining the artery walls (known as the endothelium) in the vascular system. Homocysteine causes a reduction in nitric oxide activity, impairing blood vessels’ ability to dilate and leaving the endothelium more susceptible to oxidative damage.3 Damaged vascular walls will then allow more low density lipoprotein (LDL) to be absorbed, further harming the vessel. This damage then promotes the growth of new smooth muscle cells within the vessel, which then narrows it. Endothelial damage also allows for increased platelet adhesiveness and activation of the clotting cascade, increasing the risk of cardiac arrest (heart attack) or cerebrovascular accident (stroke).

HomocysteineIn the Western world, homocysteine serum levels are most commonly found at 10-12 μmol/L. A level above 12 is generally considered elevated while levels below 6 are considered minimal. An increase of homocysteine levels by 5 μmol/L has been shown to increase the risk of cerebrovascular disease in the general population by 50 percent, and will increase the risk of coronary artery disease by 80 percent in women and 60 percent in men. In general, women have 10-15 percent less homocysteine than men during their reproductive years, which is thought in part to be the reason why women have fewer heart attacks than men, and why they tend to have them 10-15 years later than the time men commonly do.4

Genetic Causes of High Homocysteine

Dietary factors, while often cited as the chief cause for elevated homocysteine, are not the only factor. A rare hereditary disease known as homocystinuria results in several systemic disorders and is charachterized by the accumulation of homocysteine in the blood and an increased rate of excretion in the urine. Nearly 25 percent of people with this disorder die from cardiovascular complications before the age of thirty.

Ten percent of the population in general have another more common yet related condition where they are unable to effectively metabolize homocysteine and will be predisposed to the negative effects of elevated homocysteine levels, including blood clots and cardiovascular disease. This disorder is known as a methylenetetrahydrofolate-reductase (MTHFR) polymorphism genetic trait. People that have this condition are unable to effectively metabolize homocysteine and will be predisposed to the negative effects of elevated homocysteine levels, including blood clots and cardiovascular disease.

Homocysteine’s Widespread Role

Elevated homocysteine, also known as hyperhomocysteinemia, may contribute to many other conditions.


Women who have high levels of homocysteine have been shown to have a more difficult time getting pregnant and are two times as likely to have complications during pregnancy. Furthermore, women with high homocysteine levels are at risk of having miscarriages early in pregnancy.5-6 Researchers are not sure what role homocysteine has in infertility, but it has been theorized that high homocysteine contributes to subfertility, or difficulty achieving a pregnancy.

Mental Health

Elevated levels of homocysteine are also a risk factor for diseases affecting the brain. Epidemiologic studies show a dose-dependent relationship between homocysteine levels and risk for neurodegenerative diseases such as stroke, Parkinson’s disease, multiple sclerosis, and depression.7 Researchers continue to collect evidence that correlates several cardiovascular disease risk factors, homocysteine being one, with the incidence of cognitive decline and Alzheimer’s disease.8 High homocysteine by itself is considered a strong independent risk factor for dementia and Alzheimer’s disease. A study looking at data collected from the Framingham Study showed that a homocysteine level over 14 μmol/L increased the risk of developing Alzheimer’s disease by 150 percent.9

Bone Fractures

Homocysteine is considered an independent risk factor for osteoporosis fractures in the elderly.10 It is thought that homocysteine leads to fractures in the same way in which it contributes to heart disease in that homocysteine affects certain connective tissue proteins and prevents them from functioning correctly. In the case of fractures, homocysteine interferes with the cross-linking ability of collagen (a major connective tissue protein) with the tissues it supports such as the skeletal system. Because homocysteine affects the structural proteins of which bone is comprised, it does not actually affect bone density. Therefore, traditional measures used to build bones (weight bearing exercise, adequate calcium and vitamin D, etc.) will not necessarily correct the damage from homocysteine on the bones.

Controlling Elevated Homocysteine

HomocysteineCurrently, there is no standard recommendation that all people have their homocysteine levels checked. Despite this, the American Heart Association does encourage testing for homocysteine in people with a personal or family history of heart disease. In order to address all possible aspects of heart disease (and other conditions), testing homocysteine levels is a good idea.

Controlling homocysteine can be achieved by supplementing with 4 common nutrients: vitamins B6, B12, folic acid and betaine. Vitamins B6, B12, and folic acid blood levels are found to be inversely related to plasma homocysteine concentration. Combination therapy with the aforementioned vitamins provides an effective way to reduce homocysteine levels,11 and side effects of this therapy are relatively unknown.12 Another supplement that has demonstrated usefulness in lowering homocysteine levels is betaine, also known as trimethylglycine.

High dietary consumption of methionine, which can be found in meats and dairy products, can result in the overproduction of homocysteine. Once homocysteine is produced it is metabolized in the body through one of two possible pathways—remethylation or transsulfuration. Remethylation is a process that utilizes folate, vitamin B12 or betaine (trimethylglycine) to convert homocysteine back to methionine. Alternately, transsulfuration utilizes vitamin B6 (pyridoxal-5-phosphate) to break down excess homocysteine into a number of metabolites for eventual excretion from the body.13,3 B6 has been shown to be effective in reducing homocysteine levels following the ingestion of significant amounts of methionine.14

Vitamin B12 in the form of methylcobalamin is needed for the conversion (remethylation) of homocysteine back to methionine.15 This remethylation reaction also requires folic acid. B12 is thought to provide an additive effect to the lowering of homocysteine when supplied in conjunction with folic acid.16

Folic acid is needed for the metabolism of homocysteine; low levels of folate in the blood are associated with higher levels of homocysteine. Folic acid is involved in one of the two pathways (remethylation) by which homocysteine is metabolized; this pathway also requires vitamin B12. Enzymes involved in remethylation of homocysteine are dependent upon folate and vitamin B12.17-18 Supplementation with folic acid will increase the activity of the remethylation pathway and thereby reduce homocysteine levels.19

Betaine is derived from choline and occurs naturally in the body. It can also be found in foods like cereal, seafood, spinach and beets, to name a few. Betaine acts as a methyl donor and contributes in the remethylation pathway when converting homocysteine back to methionine,20 thereby reducing homocysteine levels. Betaine has been shown to lower homocysteine levels in the majority of patients unresponsive to vitamin B6 therapy. In one study, daily doses of 250 mg of vitamin B6, 5 mg of folic acid, and 6 gm of betaine by themselves or in combination normalized the majority of high homocysteine levels in patients administered high doses of methionine.21

Homocysteine-lowering strategies also include a diet low in methionine since homocysteine is an intermediate product of methionine metabolism in the body. Foods rich in methionine include cheddar cheese, eggs, chicken, and beef.


Homocysteine is considered a primary, independent risk factor for cardiovascular disease and is thought to contribute to a host of other conditions such as miscarriages and difficult pregnancy, bone fractures, strokes, blood clots, depression, dementia, Alzheimer’s and Parkinson’s diseases. Due to this amino acid’s role in a host of diseases, individuals at risk for high homocysteine levels should consider a supplement regimen that includes vitamins B12 and B6, folic acid, and betaine. The physicians at Griffin Medical Group can prescribe a treatment protocol to help lower homocysteine levels.


1. Blum A, Hijazi I, Eizenberg MM, Blum N. Homocysteine (Hcy) follow-up study. Clin Invest Med. 2007;30(1):21-5.

2. Lentz SR. Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost. 2005 Aug;3(8):1646-54.

3. Keebler ME, De Souza C, Fonesca V. Diagnosis and treatment of hyperhomocysteinemia. Curr Atheroscler Rep. 2001;3:54-63.

4. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-57.

5. D’Uva M, Di Micco P, Strina I, et al. Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report. Thromb J. 2007 Jul 11;5:10.

6. Forges T, Monnier-Barbarino P, Alberto JM, et al. Impact of folate and homocysteine metabolism on human reproductive health. Hum Reprod Update. 2007 May-Jun;13(3):225-38. Epub 2007 Feb 16.

7. Herrmann W, Lorenzl S, Obeid R. Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders–current evidence and preliminary recommendations] Fortschr Neurol Psychiatr. 2007 Sep;75(9):515-27.

8. Rosendorff C, Beeri MS, Silverman JM. Cardiovascular risk factors for Alzheimer’s disease. Am J Geriatr Cardiol. 2007 May-Jun;16(3):143-9.

9. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med. 2002 Feb 14;346(7):476-83.

10. Perier MA, Gineyts E, Munoz F, Sornay-Rendu E, Delmas PD. Homocysteine and fracture risk in postmenopausal women: the OFELY study. Osteoporos Int. 2007 Oct;18(10):1329-36.

11. Krishnaswamy K, Lakshmi AV. Role of nutritional supplementation in reducing the levels of homocysteine. J Assoc Physicians India 2002 May;50 Suppl:36-42.

12. O’Connor JJ, Meurer LN. Should patients with coronary disease and high homocysteine take folic acid? J Fam Pract. 2003 Jan;52(1):16-8.

13. Sunder-Plassmann G, Winkelmayer WC, Fodinger M. Therapeutic potential of total homocysteine-lowering drugs on cardiovascular disease. Exp Opin Invest Drugs. 2000;9:2637-51.

14. Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol. 1996;27:517-27.

15. Selhub J, Jacques PF, Bostom AG, et al. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Publ Health Rev. 2000;28:117-45.

16. Landgren F, Israelsson B, Lindgren A, et al. Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. J Intern Med. 1995;237:381-8.

17. Woodside JV, Yarnell JW, McMaster D, et al. Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. Am J Clin Nutr. 1998;67:858-66.

18. Fohr IP, Prinz-Langenohl R, Bronstrup A, et al. 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women. Am J Clin Nutr. 2002;75:275-82.

19. Vermeulen EG, Stehouwer CD, Twisk JW, et al. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet. 2000;355:517-22.

20. Brouwer IA, Verhoef P, Urgert R. Betaine supplementation and plasma homocysteine in healthy volunteers (letter). Arch Intern Med. 2000;160:2546-7.

21. Boers GHJ. Hyperhomocystinemia: A Newly Recognized Risk Factor For Vascular Disease. Netherlands Journal of Medicine. 1994; 45:34-41.

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Nov 08 2007

Pharmaceutical Grade Vitamins (supplements) vs. Regular Vitamins (supplements)

Published by under Vitamins & Supplements

Vitamins are necessary for human life and health. They are required in minute amounts, and with the exception of Vitamin B12, cannot be manufactured in your bodies. These organic compounds need to be obtained from diet, and if deprived of a particular vitamin, you will suffer from disease specific to that vitamin. It is a matter of record that you are not getting enough vitamins. Though we Americans are living longer, our quality of life leaves much to be desired.

The thirteen different vitamins are classified into two main categories:

· Water Soluble Vitamins – They dissolve easily in water. They are Vitamin C and the eight types of Vitamins B, B-1, B-2, B-3, B-5, B-6, B-7, B-9, and B-12.
· Fat Soluble Vitamins – With the help of lipids, they are absorbed through the intestinal tract. These vitamins are Vitamins A. D, E, and K.

The term Vitamin does not mean to include essential nutrients, such as, dietary minerals, essential fatty acids, or essential amino acids; neither does it mean to include other nutrients that just promote health, and may not be essential.

The Different Grades of Vitamins
Vitamin supplements are taken by more than 75% of the world’s population. With the plethora of different brands, it becomes difficult to know what is what. Vitamins and other nutritional supplements are made from three different grades of raw materials:

· Pharmaceutical Grade – It meets pharmaceutical standards
· Food Grade – It meets standards for human consumption
· Feed Grade – It meets standards for animal consumption

The main difference is of quality and purity. Due to the addition of various other substances, no product is 100% pure. Pharmaceutical Grade Vitamins must be in excess of 99% purity containing no binders, fillers, excipients – substances used as diluents for a drug – dyes, or unknown substances. Regular Vitamins of the other two grades are available as Over The Counter (OTC) products, whereas pharmaceutical grade vitamins are only available through prescriptions.

Pharmaceutical grade vitamins are formulated to yield a higher degree of bioavailability – the degree at which the vitamin is absorbed into a living system. As these vitamins can be absorbed into your body quickly, they improve and enhance the quality of your life rapidly.

Of late, the American vitamin and supplement industry has gained a bad reputation, and many feel it is rightly deserved. People walk into stores and pharmacies to buy regular vitamins. In some of the cases, the ingredients specified on the label are not in conformity with what they find inside the bottle. A variety of ingredients do not absorb into the body. The ingredients could be rancid or stale. One of the biggest culprits is omega 3 fish oil. It is probably the most bastardized supplement in the market today. Most over the counter fish oil is rancid and may contain dioxins, PCBs, aflatoxins, herbicides, pesticides, fungicides as well as unacceptable levels of heavy metals (lead, mercury, cadmium, arsenic and aluminum). Fish oil must be ultra-purified and Pharmaceutical grade. At Griffin Medical Group we prescribe our patients an ultra-purified pharmaceutical fish oil that I have taken for the past two years.  

More and more people are opting for pharmaceutical grade vitamins and supplements, as they are available through prescriptions from doctors and licensed medical practitioners. Pharmaceutical grade vitamins, vis-à-vis regular vitamins, have been tested for their quality and ability to give results. They are tested by third parties to confirm that the bottles contain what they profess to contain.


Yours in health, 


       Dr. Alan C. Ivar


A special thank you goes out to Cathy Taylor for contributing to this article.     

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Nov 08 2007

Description of Niacin – Sustained Vs. Immediate Release…

Published by under Niacin

Nicotinic acid, the water-soluble vitamin also known as niacin, has been used for many years as a cholesterol-lowering drug. It is considered a drug of first choice because it is safe and effective and has been shown to reduce the risk of heart attack.Niacin lowers total and LDL cholesterol, as well as triglycerides, and raises HDL-cholesterol as well. Niacin can lower LDL cholesterol levels as much as 30 percent. It is also the least expensive cholesterol-lowering drug.

To produce such lipid lowering, niacin is given in therapeutic doses of one and one half grams (1,500 mg) daily or more; doses of up to six grams have been used in clinical studies. Therapeutic doses usually do not exceed 3 grams daily.

Since niacin can cause severe redness and itching of the skin, therapy is usually begun with small doses and gradually increased. An aspirin given one half hour before the drug helps to reduce flushing. In addition, flushing and itching are lessened if the drug is taken on a full stomach, or if a timed-release preparation is used.

It is also helpful to begin the therapy on a non-working day to avoid any potential embarrassment that may occur from the flushing, which gradually diminishes as the body adjusts to the drug.

Sustained Release And Instant Release Niacin

The side effects of itching and flushing are minimized when taking sustained-release niacin, which allows the drug to enter the bloodstream more slowly.

However, a new study comparing two generic versions of niacin, a conventional immediate-release (IR) form and a sustained-release (SR) preparation showed that the lower rates of flushing for the SR preparation may be offset by its effect on liver function.

In the trial, 46 adults with elevated cholesterol levels were randomly assigned to take either IR or SR niacin in dosages that increased from 500 mg per day to 3 grams per day. In addition, they followed a diet that restricted saturated fat and cholesterol.

The good news for the SR niacin users was that their total cholesterol levels were lower than in patients who took the IR preparation. Also, at a dosage of 1,000 mg per day, only 22 percent had flushing, tingling, headache, warmth, or itching with SR niacin, versus 53 percent with the IR medication.

The bad news is that the patients who took the SR niacin were more likely to develop abnormalities of their liver function, which occurred with dosages as low as 1,000 mg per day. These abnormalities caused more than half of the patients taking the SR niacin to withdraw before completing the study. IR niacin did not appear to have any such effects, although other studies have shown that IR niacin can also cause serious liver-function abnormalities.

The results of this study should not lead people to discontinue taking an SR preparation that has been effective and is not causing side effects. There are a wide range of sustained-release preparations, with varying degrees of complications and effectiveness, and patients should not generalize about these agents.

Both SR and IR niacin preparations are available without prescription, and these data provide a reminder that over-the-counter drugs, like all drugs, can have side effects, and that niacin can cause liver abnormalities.

Patients taking niacin – whether IR or SR preparations – should undergo liver function tests. Before starting or stopping either form of niacin, patients should discuss the issue with their physicians.

Griffin Medical Group – Center for Anti-Aging & Aesthetics  (714) 549-6550

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Nov 08 2007

HDL and risk reduction – Sustained release niacin

Published by under Niacin

Higher HDL cholesterol for lower health risk

Many studies point to the important role of HDL cholesterol in lowering the risk of heart disease. Here are some facts from major studies:

  • For every additional point you increase HDL cholesterol, there is a 2-3 percent decrease in heart disease risk.
  • For every 10 point increase in HDL cholesterol, there is about a 50% reduction in heart disease risk

HDL cholesterol is protective.

Having high HDL cholesterol (>60) is so good for you that it can even minimize other risk factors (like high LDL cholesterol). That’s why, if your HDL level is low, your doctor will try to get it higher. (niacin sustained-release tablets) can help.

Sustained-release niacin raises HDL to lower risk

There are several kinds of cholesterol in your bloodstream.

  • LDL cholesterol carries cholesterol into your arteries, where it can form plaques that clog the flow of blood.
  • HDL takes the “bad” cholesterol out of your body.

By helping to keep plaques from forming, HDL cholesterol helps keep your blood flowing and reduces the risk of major problems like heart attack. Sustained-release niacin can help lower your risk by raising your HDL cholesterol levels.

Ask Griffin Medical Group whether sustained-release niacin may be right for you, based on your cholesterol levels and personal risk factors

(714) 549 -6550 ask for Alan

Judi Goldstone, M.D.

Alvin Yee, M.D.

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Nov 08 2007

Coenzyme Q10, Riboflavin, and Niacin Supplementation May Reduce the Risk of Cancer Recurrence and Metastases in Breast Cancer Patients

Published by under Niacin

In a study involving 84 breast cancer patients, supplementation with coenzyme Q10 (100 mg/d), riboflavin (10 mg/d), and niacin (50 mg/d), in addition to the drug, tamoxifen (10 mg/twice a day), was found to reduce circulating breast cancer markers, indicating a reduced risk of relapse. The authors point out that it is metastases at distant sites rather than the primary tumor that are the main cause of death among breast cancer patients. Levels of CEA (carcinoembryonic antigen) and CA 15-3 (carbohydrate antigen 15-3) – circulating breast cancer tumor markers – were elevated among breast cancer patients who remained untreated. After one year of treatment with tamoxifen (a drug which interferes with estrogen activity – acting against estrogen in breast tissue and acting like estrogen in other tissues), levels of circulating tumor markers decreased. When patients received supplementation with coenzyme Q10, riboflavin, and niacin, along with tamoxifen for 45 days or for 90 days (two groups), significant reductions in CEA and CA 15-3 were found. This study suggests that breast cancer patients may reduce the risk of relapse – as suggested by reduced circulating tumor markers – by adding coenzyme Q10, riboflavin, and niacin supplementation to standard tamoxifen therapy.

Reference:”Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy,” Premkumar VG, Yuvaraj S, et al, Biol Pharm Bull, 2007; 30(2): 367-70. (Address: Department of Medical Biochemistry, Dr. ALMP-GIBMS, University of Madras, Taramani Campus, and Department of Medical Oncology, Government Royapettah Hospital, Tamilnadu, India).

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Nov 08 2007

▪ Melatonin Protects Against Breast Cancer

Published by under Melatonin

It has been observed that women who work night shifts have an increased risk for breast cancer. It appears that prolonged exposure to light at night interferes with the body’s production of melatonin, a hormone produced in response to darkness. Production of melatonin peaks at night during sleep. A study published in Cancer Research investigated the role of melatonin and breast cancer. Rats with tumors composed of human breast cells were utilized in the study. Researchers injected rats with women’s blood samples of melatonin collected at various times of the day. Rats that were injected with blood samples that were low in melatonin, their tumor growth increased and rats that were injected with high melatonin samples, tumor growth significantly slowed down. The results of this study suggest that higher blood samples of melatonin may protect women against breast cancer. According to the abstract, “These results are the first to show that the tumor growth response to exposure to light during darkness is intensity dependent and that the human nocturnal, circadian melatonin signal not only inhibits human breast cancer growth but that this effect is extinguished by short-term ocular exposure to bright, white light at night”.

*Blask DE, Brainard GC, Dauchy RT, et al. Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in rats. Cancer Res. 2005 Dec 1;65(23):11174-84.

The moral of the story is “take your melatonin”

Griffin Medical Group – Center for Anti Aging &  Aesthetics  (714) 549-6550

Dr. Judi Goldstone

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Nov 08 2007

Old World Red Wines May be Healthier

Published by under Resveritrol - Red Wine

Nov. 29, 2006 — The same ingredient that helps red wines become better with age may help people live longer by protecting against heart disease.

A new study shows dry red wines high in tannins, such as those made in southwest France and in Italy, have a greater protective effect than less tannic wines produced in other parts of the world.

Tannins are compounds extracted from the seeds, skins, and stems of grapes that give red wines their characteristic dry, full taste. As a high-quality red wine ages, its sharpness softens and the flavor becomes more complex.

The amount of tannin in a red wine like cabernet sauvignon varies, depending on the winemaking methods used.

The study’s researchers say their results suggest the Old World winemaking techniques that ensure a higher amount of tannins produce wines that are healthier for the heart and may contribute to the longer longevity seen in regions known for producing such wines.

“The traditional production methods used in Sardinia and southwestern France ensure that the beneficial compounds, procyanidins [tannins], are efficiently extracted,” says researcher Roger Corder of Queen Mary’s William Harvey Research Institute of the University of London, in a news release.

“This may explain the strong association between consumption of traditional tannic wines with overall well-being, reflected in greater longevity,” he says.

Old World Reds Healthier?

Several studies have shown that moderate drinkers of red wine have less heart disease than non-drinkers; and much of the heart-healthy effects of red wine have been attributed to the antioxidant polyphenols found in the wine. These antioxidants are thought to have beneficial effects on blood vessels and arteries.

In the study, published in Nature, researchers analyzed the polyphenol content of several types of red wine produced in various parts of the world and compared the wines’ effects on blood vessel cells.

“We purified the most biologically active polyphenols, and identified them as procyanidins [condensed tannins],” says Corder.

Wines richest in these tannins had the greatest protective effect on the cells and were from regions — Sardinia and southwest France — that use Old World winemaking techniques.

Further research showed these areas are also associated with lower heart disease rates and higher longevity, he says.

The study found that wines made from the Tannat grape in southwest France were highest in these beneficial tannins. That grape is rarely grown elsewhere.

SOURCES: Corder, R. Nature, Nov. 30, 2006 online advance edition. News release, Queen Mary University of London.

Griffin Medical Group – Center for Anti-Aging & Aesthetics  (714) 549-6550

Dr. Judi Goldstone

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Nov 08 2007

A Compound in Red Wine Makes Fat Mice Healthy

Published by under Resveritrol - Red Wine

A substance found in red wine protected mice from the ill effects of obesity and extended their life spans, raising the tantalizing prospect that the compound could do the same for humans and may also help people live longer, healthier lives, researchers reported yesterday.

The substance, called resveratrol, enabled mice that were fed a high-calorie, high-fat diet to live normal, active lives despite becoming obese — the first time any compound has been shown to do that. Tests found that the agent activated a host of genes that protect against aging, essentially neutralizing the adverse effects of the bad diet on the animals’ health and longevity.

The findings could lead to the long-sought goal of extending the healthy human life span, experts said. Preliminary tests in people are underway.

“We’ve been looking for something like this for the last 100,000 years, and maybe it’s right around the corner — a molecule that could be taken in a single pill to delay the diseases of aging and keep you healthier as you grow old,” said David A. Sinclair, a Harvard Medical School molecular biologist who led the study. “The potential impact would be huge.”

The findings triggered excitement among scientists studying aging. They hailed the findings as groundbreaking.

“This represents a likely major landmark,” said Stephen L. Helfand, who studies the molecular genetics of aging at Brown University. “This really pushes the field forward. It’s quite exciting.”

The research, published online by the journal Nature, helps explain a host of observations that have long intrigued researchers, including why French people tend to have fewer heart attacks even though they have high-fat diets and why severely restricting the amount of calories that animals ingest makes them live longer.

“This gives us hope that the idea of harnessing the power of calorie restriction is not a fantasy and can be brought to reality,” said Leonard P. Guarente, who studies the biology of aging at the Massachusetts Institute of Technology. “This could produce a whole new approach to preventing and treating the diseases of aging.”

Previous research has shown that laboratory animals fed very-low-calorie diets live significantly longer, which has prompted some people to try arduous “caloric restriction” diets as a possible fountain of youth, even though their effectiveness in humans remains unproven.

In the hope of finding a drug that could harness the natural life-extending capabilities activated by caloric restriction, Sinclair and his colleagues identified a number of promising compounds, including resveratrol, which is found in red wine, grape skins, peanuts and other plants. The compound, which increases the activity of enzymes known as sirtuins, prolongs the life span of every organism scientists have tested it on, including yeast, worms, fish and fruit flies.

To examine for the first time whether resveratrol could also extend longevity in mammals, Sinclair and his colleagues studied year-old mice, which are the equivalent of middle-aged humans. One-third of the mice were fed a standard diet. Another third ate the equivalent of a junk-food diet — one very high in calories, with 60 percent of the calories coming from fat. The last third lived on the unhealthful diet combined with resveratrol.

After a year, the researchers found that both groups of mice that ate the junk-food diet got fat, and those that did not get any resveratrol experienced a host of health problems, including bloated livers and the early signs of diabetes and heart disease. They tended to die prematurely.

But the mice that received resveratrol remained healthy and were about 30 percent less likely to die, living as long as the animals that ate a normal diet and stayed thin. Preliminary results indicate resveratrol increases their life span by about 15 percent, which is the equivalent of adding perhaps about 10 human years.

Moreover, the hearts and livers of the animals getting resveratrol looked healthy, the activity of a host of key genes appeared normal, and they showed some of the biological changes triggered by caloric restriction. They also appeared to have a better quality of life, retaining their activity levels and agility.

“It is really quite amazing,” Sinclair said. “The mice were still fat, but they looked just as healthy as the lean animals.”

The researchers cautioned that the findings should not encourage people to eat badly, thinking resveratrol could make gluttony safe. They also noted that a person would have to drink hundreds of glasses of red wine a day or take megadoses of the commercially available supplements to get the levels given to the mice — doses that may not be safe. Until human studies are done, no one knows whether the findings apply to people.

But the findings indicate that resveratrol or molecules like it could have myriad benefits, and Sinclair has started taking it. Several other researchers on aging said the results tempted them to start using the supplements as well.

“I’m usually a very cautious person,” said Cynthia Kenyon of the University of California at San Francisco. “But I’m seriously thinking about taking resveratrol myself. It seems pretty wonderful.”

Said Helfand: “I actually told my mother she should take it. I even went out and got her some.”

The researchers are continuing to study the remaining living mice to gauge all the benefits, as well as other mice fed a normal diet or a calorie-restricted diet along with resveratrol to see whether the substance extends life in non-obese animals. So far the results appear promising, researchers said.

“This appears to have a lot of potential,” said Rafael de Cabo of the National Institute on Aging, which helped conduct and fund the study.

Sirtris Pharmaceuticals Inc., a biotech company in Cambridge, Mass., that Sinclair helped start and that also helped fund the mouse study, has started testing a version of resveratrol on diabetic humans. Other researchers are studying similar substances to reduce the risk of cancer.

“For now, we counsel patience,” Matt Kaeberlein and Peter S. Rabinovitch of the University of Washington wrote in an article accompanying the study. “Just sit back and relax with a glass of red wine. . . . If you must have a Big Mac, fries and apple pie, we may soon know if you should supersize that resveratrol shake.”

 For a pharmaceutical resveratrol click on the link below:

Griffin Medical Group – Center for Anti-Aging & Aesthetics  (714) 549-6550

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Nov 08 2007

Breast health and Iodine’s supportive roll

Iodine and Other Nutrients Play a Crucial Role
Jorge D. Flechas M.D., M.P.H. Over the next few weeks, the country will nationally be focusing on breast cancer. Of all the cancers women develop, 29 percent are breast cancer. By age 25, 1 in 19,608 women will develop breast cancer. By age 50, this number changes to a shocking 1 in 50 and by age 75 an even more dismal statistic: 1 in 11. In a total lifetime, one woman in 8 will develop breast cancer.

In January 2005, cancer became the leading cause of death in the United States. Each year about 211,000 cases of breast cancer are diagnosed in the USA. The number of new breast cancer cases increased from 82 per 100,000 women in 1973 to 195 per 100,000 women in 2000. The main cause of death prior to that was heart disease. The estimated death rate from breast cancer is 40,600: 40,200 females and 400 males.

Much is said in the public media about a genetic link with this cancer. Yet, genetics play only a small role in the development of breast cancer—less than 7 percent. In the September 8, 2006 issue of USA TODAY one of the lead articles was on Killer Cancer Genes ID’d. It mentioned that 122 breast cancer-causing genes have been identified. The scientist quoted in the article mentioned that we may not be able to tackle all the genes in a tumor but that we may have to work on silencing the cancer-causing genes. Doctors in the future may find that silencing even one of these genes could be enough to keep a tumor in check or kill it. They mention in the article that treatments could be a decade or more to develop.

Yet, the technology for tomorrow is here today in the supplements we have at our disposal. For example, methylation of DNA and gene silencing are affected by nutrition. Many articles exist on silencing genes and how the use of methyl-folic acid, methyl-vitamin B12, selenium, trimethylglycine powder and zinc help to methylate the DNA.

Breast Cancer Risk Factors
Many breast cancer risk factors have been identified such as a high-fat diet, low-fiber diet, tobacco use, and alcohol use. These risk factors can be modified by an individual. There are other factors that are mostly out of a woman’s control. The longer a woman is exposed to estrogen in her body, for example, the higher her risk. This would include early age at menarche, late age at menopause, long-term use of birth control pills and nulliparity (never having given birth). There seems to be a group of women whose use of birth control pills for more that 4 years puts them at higher risk before age 45. Women who take thyroid hormone are also at higher risk for developing breast cancer.1 Conversely, a lower risk for breast cancer is seen in women who are late in age at menarche, early age at menopause, and early age at first pregnancy.

Fibrocystic Breasts
In the New England Journal of Medicine, July 22, 2005 issue, there was a lead article showing that benign breast changes in women are associated with breast cancer. Benign breast changes is a new term for what we have called fibrocystic breast disease (FBD) in the past. FBD is currently affecting about 84 percent of the female population in North America.2 FBD is a misnomer because the medical problem is not a disease in the strictest sense. It is more a problem of cyclic breast pain that is associated with the menstrual cycle. In some patients the breast pain is seen daily, regardless of their menstrual cycle. Tissue biopsy for these benign breast changes that do grow larger are called proliferative lesions and if they do not grow they are called non-proliferative lesions.

Non-proliferative lesions (non-growers) can include cyst of the breast, radial scars, apocrine cells which generally make up sweat glands—the breasts are classified as a modified sweat gland—fibroadenoma, and hyperplastic cells that are normal in appearance under the microscope but are more numerous than usual. Proliferative lesions with normal cells are called sclerosing adenosis, which have a slightly increased risk (1.5 to 2 times). There are proliferative lesions with abnormal or atypical cells that are called hyperplasia—high degree with a moderate increased risk of breast cancer of (4 to 5 times), lobular neoplasia and intraductal papilloma. As a rule in medicine, the more abnormal cells look under the microscope, i.e., the more atypical the cells look, the higher the risk of cancer being present.

Iodine’s Supportive Role
Back in the early 1990s it was noted that patients who had iodine deficiency had associated benign breast changes. By giving these patient’s iodine the breast changes that were present would regress.2 It had been noticed a few years earlier that in animal studies, where the animal had been denied access to iodine, the animals developed benign breast changes like humans.3-5 In animal studies, researchers have been able to produce breast cancer in animals by depriving them of iodine.4

In my own personal medical practice I have literally seen the regression of cysts, nodules, scar tissue, and painful breast with the use of 50 mg of Iodoral® per day for 2-3 years. The breast pain goes away in just a few weeks, but the cyst/cysts, scar tissue and breast nodules take up to 2 to 3 years to resolve. On mammograms I have seen a 50 to 80 percent reduction in the scar tissue present in the breast. Studies are needed to show via biopsy that the many different types of FBD will regress with iodine supplementation.

Before starting on iodine therapy, a patient should have their thyroid hormone values investigated. A doctor should check the size of the thyroid for enlargement and or nodules. An iodine-loading test should also be done prior to starting iodine therapy to establish the need for iodine therapy. In this test the patient is given 50 mg of iodine and a 24-hour urine test is then collected. The iodine level in the urine is measured. The more saturated the body is with iodine the higher the level of iodine excreted. The more saturated the body is, the less breast abnormalities have been seen. The test is repeated at 3 months to document increasing saturation. If saturation is not occurring then further investigation is called for to find out why saturation isn’t happening.

Additional Support
Several other nutrients/hormones are also important to breast health and can be used in conjunction with Iodoral. DIM (diindolylmethane), the nutrient derived from cruciferous vegetables, for example, is influential in helping the body metabolize estrogen. DIM has been shown to change the way estrogen is metabolized. Metabolism of the natural estrogen estradiol occurs via one of two pathways. The tumor enhancer metabolic pathway, 16 alpha-hydroxylation, is elevated in patients with breast and endometrial cancer and in those at increased risk of such cancers. This increased 16 alpha-hydroxylation activity has been shown to precede clinical evidence of cancer, and it represents a significant risk factor for developing estrogen-dependent tumors.

Conversely, when estrogen veers away from the 16-alpha pathway and takes another route out of the body, the incidence of cancer decreases. This alternate route, which acts as a tumor suppressor metabolic pathway, is called 2-hydroxylation, a process that transforms estrogen into 2-hydroxyestrone (20HEI), an antiestrogen. Healthy individuals not at risk for breast or endometrial cancer bypass the 16-alpha route and instead metabolize estrogen through this preferable pathway. DIM signals the body to metabolize estrogen via the tumor suppressor 2-hydroxylation pathway.

In addition to this more well known estrogen-related mechanism of action of DIM, recent research also indicates that DIM can prevent angiogenesis, the process by which new blood vessels develop. Cancer cells use the development of new blood vessels to spread throughout the body. In mice, DIM inhibited angiogenesis by up to 76 percent.6 In addition, in mice implanted with human breast cancer cells, tumor growth was inhibited by 64 percent in animals treated with DIM.6

Another means of supporting breast health is by using natural progesterone cream. A syndrome known as Estrogen Dominance is prevalent in women, especially postmenopausal women. According to progesterone researcher Dr. John Lee, estrogen unopposed by progesterone results in a number of adverse effects including painful breasts, fibrocystic breast disease, and breast cancer.

Estrogen dominance usually occurs at menopause, when progesterone production falls to approximately 1 percent of its pre-menopausal level. At this time, the production of estrogen falls to about 50 percent of its pre-menopausal levels. This dramatically alters the estrogen: progesterone ratio, causing estrogen to become toxic without progesterone to oppose it. As a result, the risks for breast and uterine cancer and fibrocystic breast disease increase.7 Therefore, progesterone also has a crucial role to play in maintaining breast health.

Vitamin D is another breast-supportive nutrient. Women who have mutations in their vitamin D receptor gene are nearly twice as likely to develop breast cancer compared to women who do not have the mutation. The vitamin D receptor gene controls the action of vitamin D in the body. Scientists have found that Caucasian women with certain versions of this gene not only have an increased risk of breast cancer but also may suffer from a more aggressive form of the disease if it spreads. The results suggest that vitamin D does indeed play a part in protecting the body against breast cancer, as past studies indicate.

Five to ten percent of breast cancer cases are due to already established gene mutations such as BRCA1. However, the underlying cause of breast cancer in women who do not have this gene and have no family history of the disease has remained a mystery. The study suggests that the mutation in the Vitamin D receptor gene may have a role to play in disease development in women who would not ordinarily be expected to develop the disease.8

1. Ghandrakant C, Kapdim MD, Wolfe JN. Breast Cancer. Relationship to Thyroid Supplements for Hypothyroidism. JAMA. 1976; 238:1124.
2. Ghent WR, Eskin BA, Low DA, et al. Iodine Replacement in Fibrocystic Disease of the Breast. Can J Surg. 1993; 36:453-460.
3. Eskin BA, Bartuska DG, Dunn MRea. Mammary Gland Dysplasia in Iodine Deficiency. JAMA. 1967; 200:115-119.
4. Eskin BA. Iodine Metabolism and Breast Cancer. Trans New York Acad of Sciences. 1970; 32:911-947.
5. Eskin BA. Iodine and Mammary Cancer. Adv Exp Med Biol. 1977; 91:293-304.
6. Chang X, Tou JC, Hong C, Kim HA, Riby JE, Firestone GL, Bjeldanes LF. 3,3’-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis. 2005 Apr;26(4):771-8.
7. Lee, John R., What Your Doctor May Not Tell You About Menopause. Warner Books, May, 1996.
8. Guy M, Lowe LC, Bretherton-Watt D, Mansi JL, Peckitt C, Bliss J, Wilson RG, Thomas V, Colston KW. Vitamin D receptor gene polymorphisms and breast cancer risk. Clin Cancer Res. 2004 Aug 15;10(16):5472-81.

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Nov 08 2007

The Wonderful Effects of Iodine

Iodine in combination with the amino acid tyrosine is manufactured into the thyroid hormone thyroxin. Iodine intake is grossly insufficient, and since Americans have begun restricting their salt intake at the advice of their physicians, deficiency has become epidemic. The average person takes in 170-250 mcg/day of Iodine. Japanese ingest about 100 times more because of their consumption of seaweed. Japanese subjects were fed Chinese cabbage, turnips, buckwheat, and noodles with 2.0 mcg of Iodine, soybean or seaweed – goiter developed in all groups except the seaweed group.

Some 50 million Americans have a hypothyrold (low, underactive)  condition. Thyroid hormones control and regulate digestion, heart rate, body temperature, sweat gland activity, nervous and reproductive system, general metabolism and body weight.

Just because you don’t have a goiter does not mean that you have enough iodine. Deficiency has been recently associated with breast and prostate cancer.

During the early 1900’s, the iodine/iodide solution called Lugol solution was used extensively, effectively and safely in medical practice, for both low activity and above normal activity of the thyroid gland. The recommended daily intake for iodine supplementation was 2 to 6 drops of Lugol solution containing 12.5 to 37.5 mg total iodide. (Abraham, G.E., The Original Internist, 11:17-36, 2004.)

In the 1960’s, one slice of bread in the USA contained the full RDA of 0.15 mg iodine. The risk for breast cancer was then 1 in 20. (Epstein, S.S., et al, Breast Cancer Prevention Program Macmillan, NY, 1998, pg 5.)

Over the last 2 decades, iodine was replaced by bromine in the bread making process. Bromine blocks thyroid function and may interfere with the anticancer effect of iodine on the breast (Abraham, G.E., The Original Internist, 11:17-36, 2004)

Now, the risk for breast cancer is 1 in 8 and increasing 1% per year (Epstein, S.S., et al, Breast Cancer Prevention Program Macmillan, NY, 1998)

The RDA limits for vitamins and minerals were established after World War II. One of the last essential elements included in the RDA system was iodine, established in 1980 and confirmed in 1989 . The RDA for iodine was based on the amount of iodine/iodide needed to prevent goiter, extreme stupidity and hypothyroidism. The optimal requirement of the whole human
body for iodine has never been studied. Therefore, the optimal amount of this element for physical and mental well being is unknown. (Abrahams)

Iodine (iodide ions) is an essential trace mineral nutrient required to produce thyroid hormones. The element iodine occurs in food and in the body as the ionized or chemical form called iodide. The thyroid gland combines iodide with the amino acid, tyrosine, to produce thyroxin and triiodothyronine. These hormones control the body’s idling speed (Basal Metabolic Rate) and support normal growth and development.

Symptoms of iodine deficiency include sluggishness (hypothyroidism), weight gain and, in extreme cases, an enlarged thyroid gland (goiter). During pregnancy, iodine deficiency can cause severe mental retardation (cretinism) in children. Before salt was iodized in the 1920s, goiters were common in areas of the United States, especially the South, with iodine-deficient soils. Though rare, goiter sometimes occurs in women and children in certain areas of California, Texas and the South, and in Manitoba and Saskatchewan, Canada. Goiter is still common in parts of Africa. Certain substances called goitrogens in vegetables like cassava and rutabagas block iodine uptake and may contribute to the occurrence of goiter when excessive amounts of these foods are consumed.

Sources of iodide include seaweed (kelp & dulse), shellfish like shrimp, clams and oysters, marine fish and iodized salt. Iodine occurs in food in other chemical forms besides iodide. Sodium iodate, a commercial dough oxidizer, occurs in some commercially baked goods. Milk and milk products may contain traces of free iodine, used as a disinfectant for milk cows and in milk production (a Betadine-type solution is applied to the teats and udder of the cows during the milking process as an antiseptic).

The typical diet supplies more than twice the U.S. Reference Daily Intake (RDI) of 150 mcg. Consuming 2 mg per day is generally considered safe for healthy adults. Breast milk contains iodine to provide for the infant’s requirements, and lactating women require extra iodide in their diets. An additional 50 mcg of iodine per day is recommended. Iodine as supersaturated potassium iodide (SSKI) has been used clinically in the treatment of asthma, slow lymphatic drainage, sebaceous cysts, fibrocystic breast disease and to promote desirable balance of estrogens. Iodine, as a water purifier, possesses antiviral and antibacterial activity (5 drops of Tincture of Iodine per quart of water). Excessive amounts of iodide can cause iodine-induced goiter. Other side effects include rash and allergies.

Sources of Iodine that are derived from kelp or dulse (sea lettuce) are much less apt to cause any of the nasty side effects you can get from using Tincture of Iodine (antiseptic) or in the form of Potassium Iodide (expectorant) or Sodium Iodide (table salt) which are not water-soluble.
Iodized Salt
In the United States, sodium iodide has been added to table salt (sodium chloride) to create “iodized salt” since 1924. It provides 76 mcg of iodine per gram of salt. With this enrichment, goiter virtually disappeared in America. Small amounts of additives stabilize iodine in iodized salt and prevent caking: They include glucose, sodium thiocyanate, sodium aluminum silicate or sodium bicarbonate. Sea salt is not a good source of iodine. Although seawater is rich in iodide, iodide is lost during purification. Note that sea salt and iodized salt contributes the same amount of sodium as standard table salt.

Hetzel, Basil S., “The Control of Iodine Deficiency,” American Journal of Public Health, 83:4 (April 1993), pp. 494-95.

Iodine is an essential constituent of the thyroid hormones thyroxine [3,5,3'5'tetraiodothyronine (T4)] and 3,5,3′-triiodothyronine (T3). The major role of iodine in nutrition arises from the important part played by the thyroid hormones in the growth and development of humans and animals. Iodine nutritional status can be assessed by means of goiter surveys, the determination of urinary iodine excretion and the measurement of levels of thyroid hormones and of the pituitary thyroid-stimulating hormone (TSH).

Fatigue, Cold intolerance, Muscle aches & pains, Heavy or more frequent periods, Low sex drive, Brittle nails, Weight gain, Hair loss, Muscle cramps, Depression, Constipation, Elevated blood cholesterol, Puffy face, Dry skin and hair, Inability to concentrate, Poor memory, and Goiter.
See the link below for iodine supplementation:

Griffin Medical Group – Center for Anti-Aging & Aesthetics (714) 549-6550

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Nov 08 2007


By Dr. James Howenstine, MD.
November 5, 2005

Lack of iodine is widespread in the United States today. For many years iodine was added to bread in generous quantities which prevented iodine deficiency. Each slice of bread contained 150 mcg. of iodine filling the whole days RDA of iodine In 1960 the average diet consumed about 1 mg. of iodine daily with bakery products accounting for about 75 % of the total. This quantity of iodine was enough to decrease the thyroid glands ability to absorb radioactive iodine and it was also sufficient to prevent excess release of thyroid hormone thus preventing many cases of hyperthyroidism (Grave’s Disease).

Forty years ago the food industry decided to remove iodine from baked goods and replace the iodine with bromine. Iodine and bromine appear similar to the thyroid gland and bromine easily binds to the thyroid gland’s receptors for iodine. Bromine, however, is of no value to the thyroid gland unlike iodine and it inhibits the activity of iodine in the thyroid gland. Bromine also can cause impaired thinking and memory, drowsiness, dizziness and irritability. This substitution of bromine for iodine has resulted in nearly universal deficiency of iodine in the American populace. Iodine therapy helps the body eliminate fluoride, bromine, lead, cadmium, arsenic, aluminum and mercury. Could this substitution of bromine for iodine have been carried out to increase diseases and thus create more need for pharmaceutical drugs?

Among the problems caused by iodine deficiency are:

  • Underactivity of the thyroid gland produces fatigue. In rodents iodine deficiency leads to abnormal pituitary-adrenal function. The adrenal gland provides energy and stamina.
  • When iodine no longer binds to thyroid cell membranes enzymes called peroxidases are able to damage these membranes and produce autoimmune diseases such as Hashimoto’s thyroiditis and Hyperthroidism (Graves Disease). Researcher Dr. Guy Abraham has observed several cases of thyroiditis and hyperthyroidism that have been corrected by the simple replacement of iodine. For more than 100 years high doses of iodine have been known to benefit both underactivity (hypothyroidism) of the thyroid gland and overactivity of the thyroid gland (hyperthyroidism). Iodine therapy allows the sluggish thyroid gland to resume normal production of thyroid hormone leading to resolution of hypothyroidism. Provision of iodine stops the peroxidase injury to the thyroid membranes in hyperthyroidism which permits hyperthyroidism to resolve. Thus thyroid surgery for hyperthyroidism is no longer necessary.
  • Several human organs need iodine but can not absorb it until blood iodine levels reach high values (stomach, salivary glands). Most persons exhibit impaired production of stomach acid as they age. This impaired capability to produce adequate stomach acid may be a result of iodine deficiency as iodine promotes stomach acidity.
  • Resolution of cysts Iodine therapy resolves nearly every case of breast cysts. This treatment also can heal ovarian cysts and works well on skin cysts when rubbed over the cyst.
  • Iodine is found in large quantities in the brain and the ciliary body of the eye. Lack of iodine may be involved in production of Parkinson’s disease and glaucoma.
  • Lipoprotein (a) This dangerous substance is quite important as it produces plaques in arteries because it is very sticky and collects platelets, calcium and fibrin from the blood circulating inside our arteries. Excessive clotting and vascular disease resulting from high levels of lipoprotein (a) can be reversed by iodine treatment.
  • Other Health Problems Iodine has proven value in treating headaches, keloids, and parotid duct stones.

How Can Iodine Deficiency Be Detected?

An accurate test for diagnosing iodine deficiency exists. Dr. Jay Abrahams has developed a loading test to settle this issue. The patient takes 4 iodine tablets (12.5 mg each). If there is sufficient iodine in the individual the excess iodine is excreted in the urine in the next 24 hours. If iodine is lacking the body retains most of the iodine with little iodine appearing in the urine. Use of this test has shown that nearly every patient with any condition known to be associated with iodine deficiency tested positive for iodine lack. Therefore, it often is sensible to assume iodine lack and proceed to treat with iodine.

However, when a patient takes iodine for several months and has shown no improvement this test can be used to exclude a problem with absorption of iodine. Iodine lack is known to be a factor in the development of breast and prostate cancer. Sixty patients with a variety of cancers were studied. All sixty patients were found to have serious iodine deficiency.

To correct iodine deficiency by taking iodized salt is not feasible. You would need 20 teaspoons of iodized salt daily to get adequate quantities of iodine. Dr. Abrahams has developed an iodine preparation named Iodoral to treat iodine deficiency. This is composed of dried Lugol’s solution containing 12.5 mg of iodine per tablet. A person with adequate iodine stores who takes 4 of these tablets (50 mg.) will excrete 90 % of the iodine in their urine.

Dr. Abrahams thinks that the correct quantity of iodine needed to maintain sufficient amounts of iodine in the body is 13 mg. daily. This is 100 times more than the government recognized RDA for iodine. This quantity of daily iodine would be distributed as follows –six mg. to thyroid gland, five mg. for the breasts in females and two mg. for the remainder of the body. Males appear to usually, but not always, need slightly less than females.

Prominent thyroid researcher, Dr. Benjamin Eskin, has shown that the thyroid gland and skin prefer to concentrate the iodide form of iodine while the breasts concentrate iodine. His research suggested that the body needs both the iodide and iodine form of iodine. This is easy to accomplish with Lugol’s solution developed by French physician Dr. Jean Lugol in the 1820s. His solution mixed iodine (5 %) with potassium iodide (10 %) and 85 % water. Dr. Lugol’s solution killed germs and was used with success in treating infections and many other conditions. This solution in the recommended 2 drop dosage contains 5 mg. of iodine and 7.5 mg. of iodine which is exactly the quantity of iodine recommended for daily intake by Dr. Abraham. Lugol’s solution tastes metallic unless greatly diluted and stains clothing and skin.

A third solution that works well in correcting iodine deficiency is Triodide made by Scientific Botanicals of Seattle, Washington. This has the same dosage of iodine and iodide combined with a sea vegetable called bladderwrack. This can be obtained from natural food stores, Tahoma Clinic Dispensary and compounding pharmacies. This contains 12.5 mg of iodine in the same 2 drop dosage.

Dr. Abrahams recommends taking 50 mg of Iodoral (four 12.5 mg. tablets), Lugol’s solution (8 drops)or Triodide (8 drops) daily for 3 months as a loading dose. Then this dose should be gradually reduced to the 12.5 mg. maintenance dosage under the supervision of a knowledgeable health care professional. Dr.Abraham feels that 14 to 15 mg. of iodine/iodide daily is the upper maximum of safety. This is close to the recommended dose of 12.5 mg daily so caution is necessary in managing iodine repletion. Japanese researchers have discovered patients with hypothyroidism who were taking 20 mg. of iodine or more daily.

Another valuable iodine preparation is saturated solution of potassium iodide. This does not have the correct ratio of iodine iodide recommended by Dr.Abrahams for correcting iodine deficiency but it does have a multitude of valuable healing properties. It can help open up blocked arteries, disinfect water, cure bladder infections, reduce or eliminate ovarian cysts, diminish unsightly keloids, loosen thick bronchial secretions, reduce or eliminate Peyronie’s Disease and Dupuytron’s contracture.

Endocrine Cancers And Iodine Stores

Iodine deficiency is a recognized risk factor in the development of cancer of the breast, prostate, and probably the ovary and endometrium. Breast cancer is twice as common (12.1 %) in women taking natural thyroid hormone or synthetic thyroid hormone as in women not taking thyroid hormones (6.2 %). The risk for breast cancer in women taking thyroid hormones increases with time. Women who had taken thyroid hormone for 15 years had a 19.5 % incidence of breast cancer while women who had been on thyroid hormone therapy for five years had only a 10 % incidence of breast cancer. This increase in breast cancer with time suggests that correction of a iodine deficiency might well eliminate the need for thyroid hormone and would also lower the incidence of breast cancer.

Japanese women, who are eating lots of seaweed, have the highest iodine intake (13.8 mg. daily) of women anywhere in the world. They also have the lowest incidence of breast cancer in the world. Japan has one of the lowest worldwide rates of every type of cancer with the exception of stomach cancer. In addition Japan has one of the lowest incidences of iodine deficiency, goiter (enlarged thyroid gland), and hypothyroidism. Iceland, another high iodine intake country, has low rates of goiter and breast cancer. Two countries with low iodine intakes (Thailand, Mexico) have high rates of breast cancer and goiter.

Patient Studies.With Iodine Therapy

A patient of Dr. Rowen named Betty had severely painful breast cysts. She took 5 mg. of iodine daily with complete disappearance of painful breast cysts.

Veronica, another patient of Dr. Rowen, had advanced breast cancer with severe hip pain from a bone metastasis. Iodine loading test showed severe deficiency of iodine. After three months of Iodoral she still has not restored her iodine levels but her excretion of bromine has increased 10 fold. Her cancer therapy with IPT and artemisin has been stable with only an occasional IPT and she continues with 25 mg. of Iodoral three times daily. Dr. Abrahams relates that he has seen two remissions of breast cancer in persons taking 75 mg of Iodorol daily. Iodine deficiency plays a role in allowing breast cancer and prostate cancer to develop.

Another physician has seen a case of prostate cancer go into remission after taking Iodoral and supplements.

George Flechas MD relates that many of his diabetic patients need lowering of insulin dosage and diabetic drugs after repletion of iodine deficiency. Dr. Rowen has observed the same thing.

Food Sources Of Iodine

Iodine from fish must be limited because of mercury problems. However, sardines have such a short life span they do not get contaminated with mercury. My suggestion would be to buy tins of sardines packed in tomato sauce so you can avoid the transfats used in oil packed sardines.

Brown and red seaweeds contain the most iodine (kombu, focus, etc.).of sea vegetables. You may still need supplemental iodine to get an adequate quantity for repletion of iodine deficiency. unless you are eating lots of seaweeds.

Iodoral can be purchased from Optimox 310-618-9870 if you are willing to buy a case. Otherwise you can probably find this in health food stores. Lugol’s solution is a satisfactory way to obtain iodine but you will need a prescription. The dose is 2 drops daily. Be careful in measuring as 3 drops daily can lead to toxic symptoms.

The evidence presented here proves that iodine is vital to human health. Many persons will experience improved health when their iodine deficiency is corrected.

Dr. James A. Howenstine is a board certified specialist in internal medicine who spent 34 years caring for office and hospital patients. After 4 years of personal study he became convinced that natural products are safer, more effective, and less expensive than pharmaceutical drugs. 

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Nov 08 2007

Don’t Buy Omega 3 Supplements Before Reading This …

Published by under Omega-3 - Fish Oil

Not all Fish Oil and Omega 3 supplements are the same. Most supermarket and health food store brands are useless at delivering the essential fats that your body needs. Worse still, some are rancid and contaminated with toxic levels of mercury and organic pollutants. Supplement companies do not perform the stringent testing that is required to certify that their fish oil is ULTRA-PURIFIED and does not contain pollutants or contaminants. It takes 100 gallons of health food supplement grade fish oil to produce 1 gallon of ultra-purified pharmaceutical grade fish oil.

Not All Omega 3’s Contain DHA and EPA


Not all Omega 3’s will provide you with DHA and EPA. This is because these essential fatty acids are not present in a lot of Omega 3 products. For example, ground flax seed is an excellent oil for certain uses and contains Omega 3’s but does not actually contain any DHA or EPA at all. Instead it contains ALA which your body has to convert to DHA and EPA.

In many people, particularly the elderly this conversion process is very inefficient. To give you an idea, it is estimated that most adults would have to consume 10 – 40 grams of flaxseed oil to produce just 0.2 grams of DHA.

So, if you want to get the proven benefits of DHA and EPA, which include opening of blood vessels, decrease in blood clotting, decrease in inflammation and pain, killing cancer cells, improving immune system, improving mental function, stopping heart irregularities and sudden death and preventing heart disease,  don’t rely on getting your Omega 3’s from vegetable oils such as flaxseed.  Griffin Medical Group prescribes to their patients, an ultra-purified pharmaceutical grade omega 3 fish oil that is loaded with high quality DHA and EPA so patients can achieve an optimal level of health.

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Supply of hospital pharmacies operating externally due to cost savings will continue to grow all over the next years. Even today, 90% of all pharmacies pribolnichnyh organized in cooperation provisioning This shows that the Canadian pharmacy online has become not take seriously the business partner compared with the pharmaceutical industry. However, the development of recent years shows that the industry sees its price registration stronger with the number of sales, thus strengthening the competitiveness of supplying hospital pharmacies in the long term due to more efficient logistics and a lot of sales.